We analyzed the nuclear trafficking ability of Gag proteins from six retroviral genera. Contrary to a previous report, human immunodeficiency virus type 1 (HIV-1) Gag showed no propensity to cycle through the nucleus. The only Gag protein that displayed CRM1-dependent nuclear cycling was that of Rous sarcoma virus (RSV). Surprisingly, this cycling could be eliminated without compromising infectivity by replacing the RSV Gag N-terminal matrix (MA) domain with HIV MA.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318649 | PMC |
| http://dx.doi.org/10.1128/JVI.07199-11 | DOI Listing |
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