Objective: This study aimed to examine the differences in cancer risk by regional deprivation in Bavaria, Germany.
Methods: Multilevel Poisson regression analysis was used to evaluate the association between lung and colorectal cancer risk and community deprivation level based on data from the Cancer Registry of Bavaria (2003–2006). The communities (n=1,408) were classified according to the Bavarian Index of Multiple Deprivation (BIMD), differentiated into quintiles ranging from lowest to highest deprivation.
Results: Increased lung cancer risk in men and colorectal cancer risk in both genders were associated with increasing BIMD. Comparing the most deprived with the least deprived communities, the relative risk for lung cancer incidence in men was 1.39 (95% CI 1.29–1.49), for mortality risk 1.54 (95% CI 1.41–1.68). The relative risk for colorectal cancer incidence in men was 1.30 (95% CI 1.22–1.38) and in women 1.19 (95% CI 1.11–1.27); for mortality risk we found 1.57 (95% CI 1.40–1.76) in men and 1.34 (95% CI 1.19–1.51) in women.
Conclusion: Area-based deprivation is significantly associated with cancer risk in Bavaria.
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http://dx.doi.org/10.1007/s00038-012-0342-4 | DOI Listing |
Ann Intern Med
January 2025
Durham VA Health Care System, Durham; and Division of General Internal Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina (K.M.G.).
Background: Tissue-based genomic classifiers (GCs) have been developed to improve prostate cancer (PCa) risk assessment and treatment recommendations.
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Data Sources: MEDLINE, EMBASE, and Web of Science published from January 2010 to August 2024.
J Adolesc Young Adult Oncol
January 2025
Rutgers Cancer Institute, New Brunswick, New Jersey, USA.
Adolescent and young adult (AYA) survivors of acute lymphoblastic or myeloid leukemia diagnosed between the ages of 15 and 39 years are at risk for adverse late health effects following cancer treatment and require ongoing survivorship care. This study aims to understand the landscape of transitioning AYAs with leukemia from active treatment to survivorship care. A cross-sectional, anonymous online survey was sent out via listserv/email.
View Article and Find Full Text PDFPharmacogenet Genomics
January 2025
Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan.
Ibrutinib treatment is often complicated by cardiovascular side effects (CVSEs). The objective of this retrospective pharmacogenetic study is to replicate a previously reported association of 'high-risk' patients, who are homozygous carriers of at least two of GATA4 rs804280 AA, KCNQ1 rs163182 GG, and KCNQ1 rs2237895 AA, with increased risk of hypertension or atrial fibrillation, and explore associations for other pharmacogenes (e.g.
View Article and Find Full Text PDFBiol Trace Elem Res
January 2025
Department of Environmental Management and Toxicology, Federal University of Agriculture, PMB 2240, Abeokuta, Ogun State, Nigeria.
Fish is a significant source of animal protein for humans; however, it has a tendency to bioaccumulate toxicants from the environment. The present study assessed the health risks associated with potential toxic metals (PTMs) in differently processed catfish (Clarias gariepinus) from four markets in Abeokuta metropolis, southwestern Nigeria. A total of 60 samples were collected and analyzed for PTMs using an Atomic Absorption Spectrophotometer.
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