AI Article Synopsis
- The study aimed to compare the effectiveness of metformin and lifestyle changes on women with polycystic ovary syndrome (PCOS) over a 6-month period.
- Fifteen participants in the metformin group and twelve in the lifestyle group completed the trial, both showing a ~67% improvement in menstrual patterns.
- The lifestyle changes group experienced significant reductions in waist circumference, and both groups saw decreases in body mass index (BMI), with BMI being a key factor in menstrual improvement.
Article Abstract
Objective: To compare the efficacy of metformin with that of lifestyle changes in patients with polycystic ovary syndrome (PCOS).
Design: Prospective, randomized clinical trial of 40 women with PCOS to analyze the effects of metformin and lifestyle intervention treatments on menstrual pattern and hormone and metabolic profile. The duration of treatment was 6 months. Statistical analysis was done using Student's t-test.
Results: Fifteen women in the metformin group and 12 in the lifestyle changes group completed the study. The menstrual pattern improved by ~67% in both groups. There was a significant decrease in waist circumference in the lifestyle changes group (101.8 ± 3.9 and 95.1 ± 3.6, at baseline and at 6 months of treatment, respectively; p < 0.001) and in body mass index (BMI) in both groups. The predictor of menstrual pattern improvement was BMI.
Conclusions: Both metformin and lifestyle changes may increase the number of menstrual cycles in PCOS. This effect was related to a decrease in BMI.
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| http://dx.doi.org/10.3109/09513590.2011.583957 | DOI Listing |
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