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Polidocanol inhibits Enterococcus faecalis virulence factors by targeting fsr quorum sensing system.
BMC Microbiol
October 2024
Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Background: The wide spread of antimicrobial resistance in Enterococcus faecalis is a critical global concern, leading to increasingly limited treatment options. The fsr quorum sensing (QS) plays a critical role in the pathogenicity of E. faecalis, allowing bacteria to coordinate gene expression and regulate many virulence factors.
View Article and Find Full Text PDFFirst registry of patients treated with foam sclerotherapy using a new automated microfoam preparation device (2021-2022).
Phlebology
September 2024
Clínica Vascular Barcelona, Barcelona, Spain.
Article Synopsis
- A descriptive study was conducted using an automated microfoam preparation system (AMPS) for foam sclerotherapy in treating varicose veins, involving 185 patients from February 2021 to December 2022.
- The average treatment involved different volumes and concentrations of foam for various types of veins, with high occlusion rates reported after 15 months, particularly for the great and small saphenous veins.
- The study found a low complication rate overall, indicating that the AMPS could be a versatile and effective option for treating venous diseases while minimizing adverse events.
Low temperature offers better foam stability.
J Cosmet Dermatol
October 2024
Department of Cardiovascular Surgery, Ankara City Hospital, Ankara, Turkey.
Background: The foam's structural longevity, linked to the effectiveness of sclerotherapy, depends on preparation conditions. The factors enhancing the treatment's effectiveness and efficacy are still under discussion.
Methods: We conducted an in vitro preclinical research, which included 144 independent trials.
Empty vein ablation (EVA) technique: an in-vivo animal model to assess the effects of sclerosing agent concentration and wall contact time on intima and media tunicae structure.
Int Angiol
April 2024
Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
Background: Sclerotherapy is a cornerstone of the treatment of chronic venous disease, despite some technical aspects (e.g., sclerosant liquid agent concentration [SLAC] and contact time between sclerosant agent and vein wall [ctSA/VW]) to maximize outcomes remain an unsolved problem and a source of debate.
View Article and Find Full Text PDFTopical injection of sclerosant to treat cheek subcutaneous venous malformation resulting in blindness: a case report.
BMC Ophthalmol
September 2023
Department of Ophthalmology, Shenyang Fourth People Hospital, Liaoning, China.
Loss of vision after topical injection of sclerosant is a rare and uncommon complication. We describe a case with vision loss following the facial injections of physician-compounded (PCP) foam sclerotherapy which was created by room air. A 3-year-old boy underwent injection of 5ml polidocanol foamed with room air to treat the venous malformation on the cheek near the left orbit.
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