AI Article Synopsis
- A new 3D-DNA construction method allows efficient assembly of DNA strands to create scaffolds with multiple single-stranded arms for organizing functional materials in three dimensions.
- * By using ring-opening metathesis polymerization (ROMP), block copolymers are attached to the DNA strands, enhancing the structure and functionality of the DNA scaffold.
- * Site-specific hybridization of these DNA-polymer chains on the scaffold results in biohybrid cages that exhibit improved resistance to nucleases compared to traditional DNA cages.
Article Abstract
Here, we introduce a 3D-DNA construction method that assembles a minimum number of DNA strands in quantitative yield, to give a scaffold with a large number of single-stranded arms. This DNA frame is used as a core structure to organize other functional materials in 3D as the shell. We use the ring-opening metathesis polymerization (ROMP) to generate block copolymers that are covalently attached to DNA strands. Site-specific hybridization of these DNA-polymer chains on the single-stranded arms of the 3D-DNA scaffold gives efficient access to DNA-block copolymer cages. These biohybrid cages possess polymer chains that are programmably positioned in three dimensions on a DNA core and display increased nuclease resistance as compared to unfunctionalized DNA cages.
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| http://dx.doi.org/10.1021/ja210313p | DOI Listing |
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