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Summary: xQTL workbench is a scalable web platform for the mapping of quantitative trait loci (QTLs) at multiple levels: for example gene expression (eQTL), protein abundance (pQTL), metabolite abundance (mQTL) and phenotype (phQTL) data. Popular QTL mapping methods for model organism and human populations are accessible via the web user interface. Large calculations scale easily on to multi-core computers, clusters and Cloud. All data involved can be uploaded and queried online: markers, genotypes, microarrays, NGS, LC-MS, GC-MS, NMR, etc. When new data types come available, xQTL workbench is quickly customized using the Molgenis software generator.
Availability: xQTL workbench runs on all common platforms, including Linux, Mac OS X and Windows. An online demo system, installation guide, tutorials, software and source code are available under the LGPL3 license from http://www.xqtl.org.
Contact: m.a.swertz@rug.nl.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315722 | PMC |
http://dx.doi.org/10.1093/bioinformatics/bts049 | DOI Listing |
Nucleic Acids Res
January 2014
Genomics Coordination Center, University of Groningen, University Medical Center Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands, Groningen Bioinformatics Center, University of Groningen, P.O. Box 11103, 9700 CC Groningen, The Netherlands, Department of Genetics, University of Groningen, University Medical Center Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands, Department of Bioinformatics, Hanze University of Applied Sciences, Groningen, Zernikeplein 11, 9747 AS, The Netherlands and Laboratory of Nematology, Wageningen University, 6708 PB Wageningen, The Netherlands.
Interactions between proteins are highly conserved across species. As a result, the molecular basis of multiple diseases affecting humans can be studied in model organisms that offer many alternative experimental opportunities. One such organism-Caenorhabditis elegans-has been used to produce much molecular quantitative genetics and systems biology data over the past decade.
View Article and Find Full Text PDFNucleic Acids Res
January 2013
Laboratory of Nematology, Wageningen University, Wageningen 6708 PB, The Netherlands.
Bioinformatics
April 2012
Groningen Bioinformatics Centre, University of Groningen, Groningen, The Netherlands.
Summary: xQTL workbench is a scalable web platform for the mapping of quantitative trait loci (QTLs) at multiple levels: for example gene expression (eQTL), protein abundance (pQTL), metabolite abundance (mQTL) and phenotype (phQTL) data. Popular QTL mapping methods for model organism and human populations are accessible via the web user interface. Large calculations scale easily on to multi-core computers, clusters and Cloud.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!