Polycyclic cage scaffolds have been successfully used in the development of numerous lead compounds demonstrating activity in the central nervous system (CNS). Several neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, schizophrenia, and stroke, as well as drug abuse, can be modulated with polycyclic cage derivatives. These cage moieties, including adamantane and pentacycloundecane derivatives, improve the pharmacokinetic and pharmacodynamic properties of conjugated parent drugs and serve as an important scaffold in the design of therapeutically active agents for the treatment of neurological disorders. In this Minireview, we focus on the recent developments in the field of polycyclic cage compounds, as well as the relationship between the lipophilic character of these cage-derived drugs and the ability of such compounds to target and reach the CNS and improve the pharmacodynamic properties of compounds conjugated to it.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cmdc.201100559 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Electrochemical Dehydrogenative sp-Coupling Reaction of Naphthols Accessing a Polycyclic Naphthalenone Motif.
Org Lett
January 2025
Max-Planck-Institute for Chemical Energy Conversion, Stiftstraße 34-36, 45470 Mülheim an der Ruhr, Germany.
A novel polycyclic naphthalenone motif was obtained by electrochemical synthesis starting from naphthols. The process is solvent controlled, and the highly diastereoselective cyclization is due to a solvent cage. The direct, anodic dehydrogenative sp-coupling was carried out by flow electrolysis.
View Article and Find Full Text PDFEncage the Carcinogens: A Metal-"Organic Cage" Framework for Efficient Polycyclic Aromatic Hydrocarbon Removal From Water.
Small
December 2024
Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata, 700032, India.
Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic and persistent organic pollutants in water. Their removal is highly challenging for existing generic and nonspecific adsorbents, creating an urgent need for tailored solutions. Herein, a metal-"organic cage" framework, MOF-CC-1, designed for the effective scavenging of PAHs from water is is introduced.
View Article and Find Full Text PDFConformational Selection of Polymer Chains upon π-π Interactions with Small Molecules.
Phys Rev Lett
October 2024
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, Sichuan, China.
Conformational selection, pivotal in biological molecular recognition, remains underexplored in synthetic polymers, especially in the bulk states of polymers. This study reveals distinct conformational selection behavior in atactic polystyrene melts interacting with polycyclic aromatic hydrocarbons for the first time. Remarkably, despite structural similarities, anthracene and pyrene induce distinctly different conformations-trans and gauche, respectively.
View Article and Find Full Text PDFUnique Applications of -Hydrogen Matrix Isolation to Spectroscopy and Astrochemistry.
J Phys Chem Lett
November 2024
Department of Applied Chemistry and Institute of Molecular Science, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan.
Cryogenic solid -hydrogen (-H) exhibits pronounced quantum effects, enabling unique experiments that are typically not possible in noble-gas matrices. The diminished cage effect facilitates the production of free radicals via photolysis or photoinduced reactions. Electron bombardment during deposition readily produces protonated and hydrogenated species, such as polycyclic aromatic hydrocarbons, that are important in astrochemistry.
View Article and Find Full Text PDFSolvent- and Concentration-Induced Topological Transformation of a Ruthenium(II)-Based Trigonal Prism to a Triply Interlocked [2] Catenane.
Inorg Chem
November 2024
Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India.
Synthesis of interlocked supramolecular cages has been a growing field of interest due to their structural diversity. Herein, we report the template-free synthesis of a Ru(II) triply interlocked [2] catenane using coordination-driven self-assembly. The self-assembly of a triazine-based tripyridyl donor (2,4,6-tris(5-(pyridin-4-yl)thiophen-3-yl)-1,3,5-triazine) with a dinuclear Ru(II) acceptor (Ru(dhnq)(η--cymene))(CFSO)) yielded two distinct structures depending on the solvent and concentration.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!