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In vitro antioxidant, antidiabetic and antilipidemic activities of Symplocos cochinchinensis (Lour.) S. Moore bark. | LitMetric

AI Article Synopsis

  • The study investigates the medicinal properties of Symplocos cochinchinesis bark methanolic extract (SCBe), traditionally used in Indian medicine to treat diabetes.
  • In laboratory tests, SCBe demonstrated strong antioxidant effects by scavenging harmful radicals and showed high reducing power.
  • When administered to diabetic rats, SCBe significantly lowered blood glucose levels, increased insulin and liver glycogen, and improved lipid profiles, suggesting its potential as an effective antidiabetic and antilipidemic treatment comparable to glibenclamide.

Article Abstract

Symplocos cochinchinesis is used in Indian system of traditional medicine to treat diabetes mellitus. The present study investigates the in vitro antioxidant, antidiabetic and antilipidemic activities of S. cochinchinensis bark methanolic extract (SCBe) in streptozotocin (STZ) induced diabetic rats. In in vitro studies SCBe showed very good scavenging activity on 2,2-diphenyl-picrylhydrazyl (DPPH) (IC(50) 820.34 ± 1.74 μg/ml), hydroxyl (IC(50) 884.19 ± 0.45 μg/ml) and nitric oxide (IC(50) 860.21 ± 1.18 μg/ml) radicals, as well as high reducing power. SCBe (250 and 500 mg/kg) was administered to STZ (40 mg/kg) induced diabetic rats for 28 days. SCBe showed a significant decrease in blood glucose and significant increase in plasma insulin and liver glycogen levels in treated diabetic rats. Further, SCBe showed antilipidemic activity as evidenced by significant decrease in serum TC, TG, LDL-C levels and significant increase in HDL-C level in treated diabetic rats. SCBe also restored the altered plasma enzymes (SGOT, SGPT and ALP), total protein, urea and creatinine levels to near normal. The action of SCBe was comparable to the antidiabetic drug glibenclamide. Results of this experimental study indicated that SCBe possessed antioxidant, antidiabetic and antilipidemic activities.

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Source
http://dx.doi.org/10.1016/j.fct.2012.01.029DOI Listing

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