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- This study focuses on understanding how prostate cancer transitions from a non-aggressive state to an invasive one, which could improve treatment strategies for patients.
- Researchers discovered a new signaling pathway connecting low oxygen levels (hypoxia) and the PIM1 kinase to the actin cytoskeleton, crucial for cell movement.
- They found that when PIM1 modifies a protein called ABI2, it boosts cell movement and tumor invasion in prostate cancer, indicating that targeting PIM1 could be a potential therapeutic approach.
PRR16/Largen Induces Epithelial-Mesenchymal Transition through the Interaction with ABI2 Leading to the Activation of ABL1 Kinase.
Biomol Ther (Seoul)
July 2022
College of Pharmacy, Dongguk University, Goyang 10326, Republic of Korea.
Advanced or metastatic breast cancer affects multiple organs and is a leading cause of cancer-related death. Cancer metastasis is associated with epithelial-mesenchymal metastasis (EMT). However, the specific signals that induce and regulate EMT in carcinoma cells remain unclear.
View Article and Find Full Text PDFAssociation of Abl interactor 2, ABI2, with platelet/lymphocyte ratio in patients with renal cell carcinoma: A pilot study.
Int J Exp Pathol
June 2020
Department of Pathology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
There are many unknown aspects of the pathogenesis of renal cell carcinoma (RCC). The aim of the current study was to define new RCC-related genes and measure their associations with RCC and clinical parameters, especially platelet/lymphocyte ratio which may be an independent predictor of prognosis in patients with RCC and other forms of cancer. Via in silico analysis upon RCC-specific deleted genes in chromosome 3, four possible ceRNAs (ATXN3, ABI2, GOLGB1 and SMAD2) were identified.
View Article and Find Full Text PDFmiR-25 expression is upregulated in pancreatic ductal adenocarcinoma and promotes cell proliferation by targeting ABI2.
Exp Ther Med
May 2020
Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR. China.
MicroRNAs (miRNAs) are reported to play a critical role in the regulation of cancer cell proliferation; however, the role of microRNA-25 (miR-25) in pancreatic ductal adenocarcinoma (PDAC) remains unclear. In the present study, the role of miR-25 in PDAC cell proliferation was investigated. Upregulated expression of miR-25 was found in PDAC tissues and cell lines by reverse transcription-quantitative PCR.
View Article and Find Full Text PDFTIS21 inhibits doxorubicin-induced stress fiber-vimentin networks via Nox4-ROS-ABI2-DRF-linked signal cascade.
Cell Signal
January 2017
Department of Chemistry, Korea University, Seoul 02841, Republic of Korea.
Activities of TIS21 gene regulating cancer cell senescence were investigated in hepatoma cells by using low dose doxorubicin (Doxo, 100ng/mL). Treatment of Huh7 cells with Doxo increased linear actin nucleation e.g.
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