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Developing archetypes for key roles in a pragmatic trial: implementing human-centered design to promote advance care planning in primary care.
Implement Sci Commun
January 2025
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Background: Archetypes are representations of a group of people with shared behaviors, attitudes, and characteristics. The design and use of archetypes have potential application to increase partnership and support when embedding and scaling interventions but methodological approaches have not been developed.
Objective: To describe the methodology of designing archetypes for use in a pragmatic trial of advance care planning in the primary care context, SHARING Choices ((NCT04819191).
Extrication following a motor vehicle collision: a consensus statement on behalf of The Faculty of Pre-hospital Care, Royal College of Surgeons of Edinburgh.
Scand J Trauma Resusc Emerg Med
January 2025
Faculty of Pre-Hospital Care, Royal College of Surgeons Edinburgh, Edinburgh, UK.
Background: Road traffic injury is the leading cause of death among young people globally, with motor vehicle collisions often resulting in severe injuries and entrapment. Traditional extrication techniques focus on limiting movement to prevent spinal cord injuries, but recent findings from the EXIT project challenge this approach. This paper presents updated recommendations from the Faculty of Pre-Hospital Care (FPHC) that reflect the latest evidence on extrication practices.
View Article and Find Full Text PDFQuality, topics, and demographic trends of animal systematic reviews - an umbrella review.
J Transl Med
January 2025
Center for Reproducible Science, University of Zurich, Zurich, Switzerland.
Background: Animal systematic reviews are critical to inform translational research. Despite their growing popularity, there is a notable lack of information on their quality, scope, and geographical distribution over time. Addressing this gap is important to maintain their effectiveness in fostering medical advancements.
View Article and Find Full Text PDFStakeholder perspectives on facilitators and barriers to implementing a zero-dollar copay program for chronic conditions study.
Health Res Policy Syst
January 2025
Department of Maternal and Child Health, University of North Carolina Chapel Hill School of Global Public Health, Chapel Hill, United States of America.
Background: Type 2 diabetes mellitus (T2D) remains a pressing public health concern. Despite advancements in antidiabetic medications, suboptimal medication adherence persists among many individuals with T2D, often due to the high cost of medications. To combat this issue, Blue Cross and Blue Shield of Louisiana (Blue Cross) introduced the $0 Drug Copay (ZDC) program, providing $0 copays for select drugs.
View Article and Find Full Text PDFBasic Considerations for the Consistency Evaluation Based on ICH E17 Guideline.
Ther Innov Regul Sci
January 2025
Department of Biostatistics, Peking University, Beijing, China.
In the International Council for Harmonisation (ICH) guidance on General Principles for Planning and Design of Multi-Regional Clinical Trials (E17), it is important to evaluate the consistency of treatment effect across regions in a multi-regional clinical trial (MRCT). In this paper, we elaborated on some basic considerations to evaluate consistency. We first list the design considerations, and then provide consistency evaluation and interpretation on pharmacokinetics, pharmacodynamics, efficacy, safety, and benefit-risk.
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