AI Article Synopsis
- Antibodies targeting placental-binding P. falciparum may shield against malaria during pregnancy, but environmental factors play a role in their development.
- Researchers studied plasma from pregnant Malawian women to assess how bed net usage and intermittent preventive treatment (IPTp) affected IgG levels against the malaria parasite.
- Findings indicated that bed net use lowered antibody levels during mid-pregnancy, while a more intense IPTp regimen decreased antibody levels in first-time mothers (primigravidae) one month after giving birth, but not in those who had multiple pregnancies (multigravidae).
Article Abstract
Background: Antibodies towards placental-binding P. falciparum are thought to protect against pregnancy malaria; however, environmental factors may affect antibody development.
Methods And Findings: Using plasma from pregnant Malawian women, we measured IgG against placental-binding P. falciparum parasites by flow cytometry, and related results to intermittent preventive treatment (IPTp) regime, and bed net use. Bed net use was associated with decreased antibody levels at mid-pregnancy but not at 1 month post partum (1 mpp). At 1 mpp a more intensive IPTp regime was associated with decreased antibody levels in primigravidae, but not multigravidae.
Conclusions/significance: Results suggest bed nets and IPTp regime influence acquisition of pregnancy-specific P. falciparum immunity.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267709 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029874 | PLOS |
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