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Computational phantoms serve an important role in organ dosimetry and risk assessment performed at the National Aeronautics and Space Administration (NASA). A previous study investigated the impact on organ dose equivalents and effective doses from the use of the University of Florida hybrid adult male (UFHADM) and adult female (UFHADF) phantoms at differing height and weight percentiles versus those given by the two existing NASA phantoms, the computerized anatomical man (CAM) and female (CAF) (Bahadori et al 2011 Phys. Med. Biol. 56 1671-94). In the present study, the UFHADM and UFHADF phantoms of different body sizes were further altered to incorporate the effects of microgravity. Body self-shielding distributions are generated using the voxel-based ray tracer (VoBRaT), and the results are combined with depth dose data from the NASA codes BRYNTRN and HZETRN to yield organ dose equivalents and their rates for a variety of space radiation environments. It is found that while organ dose equivalents are indeed altered by the physiological effects ofmicrogravity, the magnitude of the change in overall risk (indicated by the effective dose) is minimal for the spectra and simplified shielding configurations considered. The results also indicate, however, that UFHADMand UFHADF could be useful in designing dose reduction strategies through optimized positioning of an astronaut during encounters with solar particle events.
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http://dx.doi.org/10.1088/0031-9155/57/4/1047 | DOI Listing |
APMIS
January 2025
Department of Biological Sciences, BITS Pilani K.K. Birla Goa Campus, Zuari Nagar, Goa, India.
Invasive fungal diseases are an important public health concern due to an increase in the at-risk population and high mortality associated with these infections. Managing invasive fungal infections poses a significant challenge given the limited antifungal options and the emergence of resistance in key fungal pathogens. Through a comprehensive approach, we evaluated the in vitro antifungal activity and the in vivo efficacy of two novel lipopeptides, AF and AF in murine models of disseminated candidiasis, cryptococcosis, and aspergillosis.
View Article and Find Full Text PDFVet Q
December 2025
School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, Australia.
This study evaluated the impact of vaccine diluents (peptone or water) on the protective effects of Typhimurium (. Typhimurium) vaccine. Vaccinated broilers were challenged with different doses of wild-type .
View Article and Find Full Text PDFBrachytherapy
December 2024
Department of Physics, Mwalimu Julius K. Nyerere University of Agriculture and Technology, Musoma, Tanzania.
Background And Purpose: Cervical cancer is the most prevalent type of cancer among women in numerous low and middle-income countries. Tandem-based applicator is a widely used technique in High Dose Rate Intercavitary Brachytherapy (HDR-ICBT) for treating cervical cancer. For cases where central tandem insertion is not feasible due to patient-specific conditions, a ring-only applicator is used as an alternative.
View Article and Find Full Text PDFEnviron Int
December 2024
UniSA Clinical and Health Sciences, University of South Australia, City East Campus, 5000, Australia.
A Sprague-Dawley rat model was utilized to elucidate perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) toxicokinetics with a goal of developing an in vivo approach for quantifying PFAS relative bioavailability in impacted soil. Following single dose administration (gavage) of ∼ 0.2-2000 µg kg BW of PFOA, PFOS or PFHxS, differences in PFAS blood, organ and excreta concentrations were observed over 120 h although linear dose responses were determined for area under the blood plasma time curves (AUC; PFOA, PFHxS), liver accumulation (LA: PFOS) and urinary excretion (UE; PFOA, PFHxS).
View Article and Find Full Text PDFFront Oncol
December 2024
Radiotherapy Department, Montpellier Regional Cancer Institute, Montpellier, France.
Introduction: Following a preliminary work validating the technological feasibility of an adaptive workflow with Ethos for whole-breast cancer, this study aims to clinically evaluate the automatic segmentation generated by Ethos.
Material And Methods: Twenty patients initially treated on a TrueBeam accelerator for different breast cancer indications (right/left, lumpectomy/mastectomy) were replanned using the Ethos emulator. The adaptive workflow was performed using 5 randomly selected extended CBCTs per patient.
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