Dihydrofolate reductase single-chain variable fragment (scFv) fusion proteins can be used for the targeted cellular delivery of oligonucleotides, conjugated small molecules, and proteins via labeling of oligonucleotides by bis-methotrexate.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312035PMC
http://dx.doi.org/10.1021/ja210894gDOI Listing

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