AI Article Synopsis
- The study analyzed blood serum content related to collagen breakdown and inflammation in 73 patients with chronic pancreatitis (CHP), finding that increased levels of oxygenated proline, elastase activity, and glycosaminoglycans correlate with the severity of the disease.
- In terms of disease staging, 35.6% of patients were classified as stage B, while 24.6% were in stage C1, 23.4% in stage C2, and 16.4% in stage C3, indicating varying levels of chronic pancreatitis severity.
- The research suggests that measuring neutrophil elastase and oxyproline levels in the blood could serve as useful additional diagnostic tools for assessing pancreatic pathology
Article Abstract
A content in the blood serum of a free and connected oxyproline, collagenolytic activity of the blood, the level of glycosaminoglycans and elastase activity was detected in chronic pancreatitis (CHP). There were examined 73 patients (64 men and 9 women). CHP in a stage B (according to M. Buchler et al., 2009) was established in 26 (35.6%) patients, C1 - in 18 (24.6%), C2 - in 17 (23.4%), C3 - in 12 (16.4%). A progress of pancreatic fibrosis in CHP have occurred on a background of a high activity of elastase in neutrophils, a glycosaminoglycans level raising, as well as a free and connected oxyproline. A detection of a neutrophils elastase activity and oxyproline content in the blood serum may be used in a clinical practice as additional diagnostic criteria of estimation of the pancreatic pathology severity. The changes revealed were the same as in CHP of alcoholic and of the other nature.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!