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ERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells.
Cell Rep
January 2025
Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, 72076 Tübingen, Baden-Württemberg, Germany; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, 72076 Tübingen, Baden-Württemberg, Germany. Electronic address:
Epithelial cells respond to infection with the intracellular bacterial pathogen Listeria monocytogenes by altering their mechanics to promote collective infected cell extrusion (CICE) and limit infection spread across cell monolayers. However, the underlying biochemical pathways remain elusive. Here, using in vitro (epithelial monolayers) and in vivo (zebrafish larvae) models of infection with L.
View Article and Find Full Text PDFNovel Strategies for the Treatment of Lung Cancer: An In-depth Analysis of the Use of Immunotherapy, Precision Medicine, and Artificial Intelligence to Improve Prognoses.
Curr Med Chem
January 2025
Shree S K Patel College of Pharmaceutical Education and Research, Ganpat University, Mahesana, Gujarat, 384012, India.
Therapeutic hurdles persist in the fight against lung cancer, although it is a leading cause of cancer-related deaths worldwide. Results are still not up to par, even with the best efforts of conventional medicine, thus new avenues of investigation are required. Examining how immunotherapy, precision medicine, and AI are being used to manage lung cancer, this review shows how these tools can change the game for patients and increase their chances of survival.
View Article and Find Full Text PDFEducate, Advocate, Act Now: a sustainable approach to combating antimicrobial resistance TODAY.
J Antimicrob Chemother
January 2025
Department of Biotechnology, Nigeria Defence Academy, Kaduna, Nigeria.
Antimicrobial resistance (AMR) poses a great challenge to health systems all over the world. It is exacerbated by the abuse, misuse and overuse of antimicrobials in humans, animals, plants and the environment. This viewpoint emphasizes the critical need to address the challenges of AMR through an integrated, long-term approach that focuses on education, advocacy and collective action.
View Article and Find Full Text PDFLessons Learned from COVID-19 Pandemic in Combating Antimicrobial Resistance-Experience of Hong Kong, China.
Microorganisms
December 2024
World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
The world has gone through the COVID-19 pandemic and has now returned to normalcy. We reviewed the strategies and public health actions conducted in Hong Kong during the COVID-19 pandemic, and reflected on the lessons learned, which are potentially useful in the fight against antimicrobial resistance (AMR). We recommended extending wastewater surveillance for AMR, apart from SARS-CoV2.
View Article and Find Full Text PDFThe impact of inflammatory response on psychological status of medical staff during COVID-19 pandemic.
Psicol Reflex Crit
January 2025
The Affiliated Infectious Hospital of Soochow University, 10 Guangqian Road, Suzhou, Jiangsu, 215131, China.
Background: Limited research has been conducted on the relationship between inflammatory markers and psychological status in medical staff fighting COVID-19.
Objective: This article examines the psychological and inflammatory conditions of medical personnel working on the front lines of the battle against COVID-19.
Methods: A total of 102 clinical staff members were included in this study.
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