AI Article Synopsis

  • Recipients of solid organ transplants have a higher risk of developing cutaneous squamous cell carcinoma (SCC), prompting research into various risk factors.
  • A case-control study was conducted, including 207 SCC patients and 189 matched controls based on age and transplant date, with data collected through thorough medical record reviews.
  • The study found no significant links between SCC risk and factors like post-transplant infections, HLA types, or donor characteristics, indicating that these factors may not play a major role in developing SCC post-transplant.

Article Abstract

Recipients of solid organ transplants are at a markedly increased risk of cutaneous squamous cell carcinoma (SCC). We investigated potential associations between post-transplant infections, HLA type, and other transplant-related factors and risk of SCC, taking immuno-suppressive treatment into account. A population-based case-control study was conducted. All patients who developed SCC during follow-up (1970-1997) were eligible as cases (n = 207). Controls (n = 189) were individually matched to the cases on age and calendar period of transplantation. Detailed exposure information was collected through an extensive, blinded review of medical records. Odds ratios were computed with conditional logistic regression. There were no significant associations with any infectious agents, or with number and timing of infections, specific HLA-type, donor characteristics, or other transplant characteristics and risk of post-transplant SCC. These results suggest that risk of post-transplant SCC is neither closely related to specific post-transplant infectious disorders, nor to the infectious load or specific HLA types.

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Source
http://dx.doi.org/10.2340/00015555-1271DOI Listing

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