AI Article Synopsis
- The investigation of the methanolic extract of Fissistigma latifolium led to the discovery of two new compounds: 2,5,6,7-tetramethoxyflavan and 2'-hydroxy-4',5',6'-trimethoxybenzil.
- The structures of these compounds were confirmed through various chemical and spectroscopic methods, with compound 2 being the first benzil reported from Fissistigma species.
- Notably, 2,5,6,7-tetramethoxyflavan exhibited a strong ability to inhibit the production of superoxide anions in activated human neutrophils.
Article Abstract
Further investigation of the methanolic extract of Fissistigma latifolium resulted in two new compounds whose structures were assigned as 2,5,6,7-tetramethoxyflavan (1) and 2'-hydroxy-4',5',6'-trimethoxybenzil (2). These two compounds were determined on the basis of chemical and spectroscopic evidences. Compound 2 is the first report of benzil from Fissistigma species. 2,5,6,7-Tetramethoxyflavan (1) showed a potent inhibitory effect on superoxide anion production in formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)/cytochalasin B (CB)-activated human neutrophils.
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| http://dx.doi.org/10.1248/cpb.60.280 | DOI Listing |
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