AI Article Synopsis
- Cholecystokinin (CCK), a neurotransmitter prevalent in the brain, may play a role in panic and anxiety disorders.
- CCK-tetrapeptide can trigger panic attacks similar to those experienced by individuals with panic disorder, indicating that they may be more sensitive to its effects.
- Studies show that using CCK antagonists in animal models reduces the anxiety caused by CCK agonists, supporting the idea that CCK is involved in these disorders.
Article Abstract
It has been suggested that cholecystokinin, a neurotransmitter found in high density in mammalian brain, might be implicated in the neurobiology of panic and anxiety disorders. Cholecystokinin-tetrapeptide induces panic attacks analogous to spontaneous panic attacks in patients suffering from panic disorder and to a much lesser degree in healthy volunteers, suggesting an enhanced sensitivity to cholecystokinin-tetrapeptide in panic disorder. In animal models of anxiety, pre-treatment with cholecystokinin antagonists significantly decreases the anxiogenic effects of cholecystokinin agonists. This paper reviews clinical and basic studies supporting an involvement for cholecystokinin in panic and anxiety disorders.
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| http://dx.doi.org/10.1177/026988119200600301 | DOI Listing |
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