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Phase I study of BMS-986299, an NLRP3 agonist, as monotherapy and in combination with nivolumab and ipilimumab in patients with advanced solid tumors.
J Immunother Cancer
January 2025
Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Purpose: BMS-986299 is a first-in-class, NOD-, LRR-, and pyrin-domain containing-3 (NLRP3) inflammasome agonist enhancing adaptive immune and T-cell memory responses.
Materials And Methods: This was a phase-I (NCT03444753) study that assessed the safety and tolerability of intra-tumoral BMS-986299 monotherapy (part 1A) and in combination (part 1B) with nivolumab, and ipilimumab in advanced solid tumors. Reported here are single-center results.
Different effects of tocopherol natural extract on sunflower oil stability under frying and accelerated storage conditions: A comprehensive study on the fate of major and minor components of oil, and added tocopherols.
Food Chem
January 2025
Food Technology, Faculty of Pharmacy, Lascaray Research Center, University of the Basque Country (UPV/EHU). Paseo de la Universidad n° 7, 01006 Vitoria-Gasteiz, Spain. Electronic address:
The effect of adding a tocopherol-rich natural extract (TNE) at 0.1 % and 0.5 % on sunflower oil stability under frying and accelerated storage conditions was studied using H NMR and DI-SPME-GC/MS.
View Article and Find Full Text PDFSunlight-mediated environmental risks of tinidazole in seawater: A neglected ocular toxicity of photolysis mixtures.
J Hazard Mater
January 2025
Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology, Xiamen University, Xiamen 361102, China; State Key Laboratory of Mariculture Breeding, Xiamen University, Xiamen 361102, China. Electronic address:
Tinidazole (TNZ), a common nitroimidazole antibiotic, is pervasive in aquatic ecosystems, posing potential threats to marine organisms. The environmental fate of TNZ, particularly under solar irradiation, and the associated secondary risks are not well characterized. Herein, the photochemical reactivity of TNZ and four other typical nitroimidazoles (i.
View Article and Find Full Text PDFTransformation fate of bisphenol A in aerobic denitrifying cultures and its coercive mechanism on the nitrogen transformation pathway.
Environ Res
January 2025
State Key Laboratory of Marine Pollution and Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Hong Kong, Kowloon, 999077, China; School of Energy and Environment, City University of Hong Kong, Tat Chee Avenue, Hong Kong, Kowloon, 999077, China.
Bisphenol A (BPA) is a commonly used endocrine-disrupting chemical found in high levels in wastewater worldwide. Aerobic denitrification is a promising alternative to conventional nitrogen removal processes. However, the effects of BPA on this novel nitrogen removal process have rarely been reported.
View Article and Find Full Text PDFArticle Synopsis
- FT596 is a novel cancer therapy using iPSC-derived CAR NK cells targeting CD19, designed to assess its safe dosage and effectiveness alone and with rituximab in patients with B-cell lymphoma.
- This phase 1 trial involved patients with relapsed or refractory B-cell lymphoma, administering FT596 after chemotherapy, with separate regimens for those receiving rituximab and those who did not.
- The study measured potential side effects while determining the optimal dose of FT596 and allowed modifications to the treatment based on patient tolerance and response.
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