One-pot Crabbé homologation-radical cascade cyclisation with memory of chirality.

Chem Commun (Camb)

Institut de Chimie Radicalaire (ICR), UMR 7273, Aix-Marseille Université, Faculté de St Jérôme, Avenue Escadrille Normandie-Niemen, 13397 Marseille Cedex 20, France.

Published: March 2012

The tandem Crabbé homologation-radical rearrangement of terminal enediynes leads, in a one-pot procedure, to the enantioselective synthesis of six- and seven-membered ring α-aminoesters bearing a quaternary stereocenter based on the phenomenon of memory of chirality.

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http://dx.doi.org/10.1039/c2cc17830cDOI Listing

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One-pot Crabbé homologation-radical cascade cyclisation with memory of chirality.

Chem Commun (Camb)

March 2012

Institut de Chimie Radicalaire (ICR), UMR 7273, Aix-Marseille Université, Faculté de St Jérôme, Avenue Escadrille Normandie-Niemen, 13397 Marseille Cedex 20, France.

The tandem Crabbé homologation-radical rearrangement of terminal enediynes leads, in a one-pot procedure, to the enantioselective synthesis of six- and seven-membered ring α-aminoesters bearing a quaternary stereocenter based on the phenomenon of memory of chirality.

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