AI Article Synopsis
- Phytochemical analysis of Smilax ornata (sarsaparilla) revealed five steroidal saponins, including two new compounds named sarsaparilloside B and sarsaparilloside C.
- The structures of these saponins were determined using advanced techniques like mass spectrometry and NMR, including new details on previously unreported saponins.
- Antiproliferative testing showed that sarsaparilloside C was especially effective against colon cancer cells (HT29).
Article Abstract
Phytochemical characterization of a commercial herb sample supplied as Smilax ornata Lem. (sarsaparilla) led to the isolation of five steroidal saponins, including two new furostanol saponins sarsaparilloside B (1) and sarsaparilloside C (2), whose structures were elucidated via a combination of multistage mass spectrometry (MS(n)), 1D and 2D NMR experiments, and chemical degradation. The previously unreported spectroscopic characterization of sarsaparilloside (3), Δ(20(22))-sarsaparilloside (4), and parillin (5) is also provided. The antiproliferative activity of the isolated saponins was compared in six human cell lines derived from different tumor types and one of the structures (2) was particularly active against the HT29 colon tumor cell line.
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| http://dx.doi.org/10.1016/j.steroids.2012.01.009 | DOI Listing |
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