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Background And Aims: Sensitivity to immune checkpoint inhibitor (ICI) therapy depends in part on the genetic and epigenetic makeup of cancer cells, and CD8 T-lymphocytes that mediate immune responses. Epigenetics are heritable reversible changes in gene expression that occur without any changes in the nuclear DNA sequence or DNA copy number.
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Pulmonology, Algemeen Ziekenhuis Glorieux, Ronse, BEL.
Heterotaxy syndrome is characterized by abnormal left-right arrangement of thoracoabdominal organs and is frequently associated with complex cardiac anomalies. However, cases with predominant extracardiac manifestations are increasingly recognized. This report describes a 20-year-old female of North African descent with consanguineous parentage, who presented with chronic cough and exertional dyspnea persisting over several years.
View Article and Find Full Text PDFNovel methods for the detection of glutathione by surface-enhanced Raman scattering: A perspective review.
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Department of Chemical Engineering, Fahd University of Petroleum & Minerals (KFUPM), Dhahran, 31261, Kingdom of Saudi Arabia.
Detection of biomolecules, Glutathione (GSH) in particular, is important because it helps assess antioxidant capacity, cellular protection, detoxification processes, and potential disease associations. Monitoring glutathione levels can provide valuable information about overall health and well-being. Many medical disorders have been connected to glutathione levels.
View Article and Find Full Text PDFCircular RNA circAGAP1 promotes sunitinib sensitivity in renal cell carcinoma via sponging multiple PDGFR-targeted miRNAs.
Oncol Res
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Imaging Department, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
Background: Sunitinib resistance is a major challenge in advanced renal cell carcinoma (RCC). Clinically, elucidating the underlying mechanisms and developing practical countermeasures for sunitinib resistance in RCC is desirable. In previous studies, we found that circAGAP1 expression was significantly upregulated in clear cell RCC (ccRCC) and was strongly associated with poor prognosis.
View Article and Find Full Text PDFOptically Readable Multilevel Magnetic Memory States in Perpendicularly Exchange-Biased Ferromagnetic Multilayers.
Small
January 2025
Department of Physics, Kyungpook National University, Daegu, 41566, South Korea.
The construction of multilevel magnetic states using materials with perpendicular magnetic anisotropy (PMA) offers a novel approach to enhancing the storage density and read/write efficiency of nonvolatile magnetic memory devices. In this study, optically readable multilevel magnetic domain states are achieved by inducing asymmetric interlayer interactions and decoupling the magnetic reversal behavior of individual ferromagnetic (FM) layers in exchange-biased FM multilayers with PMA. Hepta-level magnetic domain states are formed in [Co/Pt] FM multilayers grown on an antiferromagnetic FeO layer within a relatively low magnetic field range of ∼±400 Oe.
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