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The transmembrane protein TMEM196 controls cell proliferation and determines the floor plate cell lineage.
Dev Growth Differ
January 2025
Division of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Japan.
The neural tube, the embryonic precursor to the vertebrate central nervous system, comprises distinct progenitor and neuronal domains, each with specific proliferation programs. In this study, we identified TMEM196, a novel transmembrane protein that plays a crucial role in regulating cell proliferation in the floor plate in chick embryos. TMEM196 is expressed in the floor plate, and its overexpression leads to reduced cell proliferation without affecting the pattern formation of the neural tube.
View Article and Find Full Text PDFMachine learning analysis of rivaroxaban solubility in mixed solvents for application in pharmaceutical crystallization.
Sci Rep
January 2025
Department of Oral & Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, 21944, Taif, Saudi Arabia.
This study investigates the use of machine learning models to predict solubility of rivaroxaban in binary solvents based on temperature (T), mass fraction (w), and solvent type. Using a dataset with over 250 data points and including solvents encoded with one-hot encoding, four models were compared: Gradient Boosting (GB), Light Gradient Boosting (LGB), Extra Trees (ET), and Random Forest (RF). The Jellyfish Optimizer (JO) algorithm was applied to tune hyperparameters, enhancing model performance.
View Article and Find Full Text PDFEfficient IP address retrieval using a novel octet based encoding technique for high speed lookup to improve network performance.
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Department of Information Systems, Faculty of Computing and Information Technology, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
As the Internet becomes increasingly popular, the number of users connected to it grows significantly. Consequently, the packet processing speed of network systems, such as routers, must be enhanced. IP lookup is a critical task used to find the next hop address by searching for the longest prefix match in the forwarding information base (FIB).
View Article and Find Full Text PDFDynamic hydrogen-bonding enables high-performance and mechanically robust organic solar cells processed with non-halogenated solvent.
Nat Commun
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CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.
Developing active-layer systems with both high performance and mechanical robustness is a crucial step towards achieving future commercialization of flexible and stretchable organic solar cells (OSCs). Herein, we design and synthesize a series of acceptors BTA-C6, BTA-E3, BTA-E6, and BTA-E9, featuring the side chains of hexyl, and 3, 6, and 9 carbon-chain with ethyl ester end groups respectively. Benefiting from suitable phase separation and vertical phase distribution, the PM6:BTA-E3-based OSCs processed by o-xylene exhibit lower energy loss and improved charge transport characteristic and achieve a power conversion efficiency of 19.
View Article and Find Full Text PDFComparative analysis of patient demographics and outcomes in teaching and non-teaching hospitals in Iran.
Hosp Pract (1995)
January 2025
Education Development Center, Iran University of Medical Sciences, Tehran, Iran.
Aims: This study investigates the differences in patient demographics and outcomes between teaching and non-teaching hospitals in Iran. By analyzing these differences, it aims to provide useful information for policymakers to optimize resource allocation, improve patient care, and balance educational and service delivery goals in teaching hospitals.
Materials And Methods: In this cross-sectional investigation, both teaching and non-teaching general hospitals were examined.
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