The formation of azoxymethane, a colon carcinogen, during the chemical oxidation of methylamine.

Carcinogenesis

Division of Molecular Biology and Pharmacology, Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, NY 10595, USA.

Published: January 1980

Simple chemical oxidation of methylamine in aqueous solution or in methanol leads to the formation of significant amounts of azoxymethane, a strong carcinogen in rodents. Methods, including high pressure liquid chromatography, differential pulse polarography and gas chromatography-mass spectrometry, used for the identification of the carcinogen, are described.

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http://dx.doi.org/10.1093/carcin/1.1.57DOI Listing

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