A comparison of sulpiride, dothiepin, diazepam and placebo in the treatment of depressed out-patients.

The effects of sulpiride, dothiepin, diazepam and placebo were compared in out-patients who were suffering from depressive states of moderate severity. No major differences were found between the regimens after 4 weeks administration. A notable finding was the high recovery rate among those patients who received the placebo. The need for drug treatment in the milder depressive states is discussed.