AI Article Synopsis
- The study investigates the anticonvulsant effects of Acorus calamus (HAEAC) when combined with traditional antiepileptic drugs (AEDs) like sodium valproate and carbamazepine in a rat model.
- The combination of HAEAC with these AEDs resulted in better seizure protection than using either drug alone, indicating enhanced effectiveness.
- Importantly, this improved protection did not correlate with changes in the levels of the conventional AEDs in the body, suggesting a promising role for HAEAC as an add-on therapy.
Article Abstract
Anticonvulsant property of Acorus calamus is known. Since combination therapy can lower the dose of individual drug and dose related toxicities, in this study, the effect of co-administration of hydroalcoholic extract of A. calamus (HAEAC) on conventional antiepileptic drugs (AEDs), sodium valproate and carbamazepine was determined using pentylenetetrazole-induced seizures model in rats. On combining the subanticonvulsant doses of HAEAC with sodium valproate and carbamazepine, greater protection as compared to either drug alone was observed. This was not related to change in levels of the AEDs. Thus, the results further substantiate anticonvulsant effect of HAEAC and suggest a potential for add on therapy with AEDs.
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