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Acceptability and feasibility of a urine-based tenofovir adherence assay for monitoring and providing feedback on PrEP adherence in Kenya.
AIDS Care
December 2024
School of Public Health, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.
Objective measures of oral PrEP adherence - especially point-of-care (POC) measures that enable real-time assessment, intervention, and feedback - have the potential to improve adherence. Our team previously developed and validated a novel urine-based POC metric of PrEP adherence. In this study, we sought to determine whether this assay is acceptable and feasible among women taking PrEP and PrEP providers in Kenya.
View Article and Find Full Text PDFInvestigating the effects of stereotactic body radiation therapy on pancreatic tumor hypoxia and microvasculature in an orthotopic mouse model using intravital fluorescence microscopy.
Sci Rep
December 2024
Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Despite decades of improvements in cytotoxic therapy, the current standard of care for locally advanced pancreatic cancer (LAPC) provides, on average, only a few months of survival benefit. Stereotactic Body Radiation Therapy (SBRT), a technique that accurately delivers high doses of radiation to tumors in fewer fractions, has emerged as a promising therapy to improve local control of LAPC; however, its effects on the tumor microenvironment and hypoxia remain poorly understood. To explore how SBRT affects pancreatic tumors, we combined an orthotopic mouse model of pancreatic cancer with an intravital microscopy platform to visualize changes to the in vivo tumor microenvironment in real-time.
View Article and Find Full Text PDFEEG-based emotion recognition using multi-scale dynamic CNN and gated transformer.
Sci Rep
December 2024
School of Electronic Information and Electrical Engineering, Yangtze University, Jingzhou, 434100, Hubei, China.
Emotions play a crucial role in human thoughts, cognitive processes, and decision-making. EEG has become a widely utilized tool in emotion recognition due to its high temporal resolution, real-time monitoring capabilities, portability, and cost-effectiveness. In this paper, we propose a novel end-to-end emotion recognition method from EEG signals, called MSDCGTNet, which is based on the Multi-Scale Dynamic 1D CNN and the Gated Transformer.
View Article and Find Full Text PDFNumerical optimization of anti resonant hollow core fiber for high sensitivity methane detection.
Sci Rep
December 2024
Faculty of Electrical Engineering, Shahid Rajaee Teacher Training University, Tehran, Iran.
This study presents an innovative methane gas sensor design based on anti-resonant hollow-core fiber (AR-HCF) technology, optimized for high-precision detection at 3.3[Formula: see text]. Our numerical analysis explores the geometric optimization of the AR-HCF's structural parameters, incorporating real-world component specifications.
View Article and Find Full Text PDFReduced bacteria concentrations in wastewater is a key indicator of the efficacy of water resource recovery facilities (WRRFs). However, monitoring the presence of bacterial concentrations in real time at each stage of the WRRF is challenging as it requires taking and processing water samples offline. Although few studies have been proposed to predict bacterial concentrations using data-driven models, generalizing these models to unseen data from different WRRFs remains challenging.
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