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Physician experience and rates of plasma HIV-1 RNA suppression among illicit drug users: an observational study. | LitMetric

AI Article Synopsis

  • The study focuses on improving treatment outcomes for HIV-positive illicit drug users receiving antiretroviral therapy (ART), particularly by evaluating how physician experience affects HIV-1 RNA suppression rates.
  • Researchers analyzed a cohort from 1996 to 2008 and found that 85% of participants achieved viral suppression, with greater physician experience linked to better outcomes.
  • The study suggests the need for specialized healthcare services to optimize HIV treatment for this population, highlighting the importance of physician expertise alongside factors like adherence to ART and engagement in therapies like methadone.

Article Abstract

Background: Despite the availability of antiretroviral therapy (ART), suboptimal treatment outcomes have been observed among HIV-seropositive illicit drug users. As there is an urgent need to improve responses to antiretroviral therapy among this population, we undertook this study to evaluate the role of physician experience on rates of plasma HIV-1 RNA suppression following initiation of ART.

Methods: Using data from a community-recruited cohort of HIV-positive illicit drug users, we used Cox proportional hazards regression to model the time to plasma viral HIV RNA < 500 copies/mL among antiretroviral-naïve subjects initiating ART. Physician experience was defined as a continuous variable measured per 100 HIV-infected patients previously enrolled in the province-wide HIV treatment registry by that physician at the time a patient was enrolled.

Results: Between May 1996 and December 2008, 267 individuals initiated ART among whom 227 (85%) achieved a plasma HIV RNA < 500 copies/mL during the study period. In a multivariate analysis, greater physician experience was independently associated with higher rates of plasma HIV RNA suppression (adjusted hazard ratio [AHR] = 1.17, 95% confidence interval [CI]: 1.03-1.34) after adjustment for adherence to ART. Other factors associated with viral suppression included engagement in methadone maintenance therapy (AHR = 1.61, 95% CI: 1.23-2.09), ≥ 95% adherence to ART (AHR = 2.42, 95% CI: 1.80-3.26), baseline CD4 count (AHR = 0.89, 95% CI: 0.83-0.96) and baseline plasma HIV-1 RNA (AHR = 0.65, 95% CI: 0.53-0.81).

Conclusions: In this setting of universal HIV/AIDS care, illicit drug users with more experienced physicians exhibited faster rates of plasma viral load suppression. These findings argue for specialized services to help optimize HIV treatment outcomes among this population.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285077PMC
http://dx.doi.org/10.1186/1471-2334-12-22DOI Listing

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