An efficient conversion of 4-bromo-3-yn-1-ols to γ-butyrolactones via AuCl(3)-catalyzed electrophilic cyclization (hydroxyl-assisted regioselective hydration) in wet toluene is described. Various secondary and tertiary alcohols including benzylic systems were found to be equally reactive with moderate to excellent yields obtained in all cases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol2033493 | DOI Listing |
Publication Analysis
Top Keywords
synthesis γ-butyrolactones
4
γ-butyrolactones aucl3-
4
aucl3- hgii-catalyzed
4
hgii-catalyzed intramolecular
4
intramolecular hydroalkoxylation
4
hydroalkoxylation 4-bromo-3-yn-1-ols
4
4-bromo-3-yn-1-ols efficient
4
efficient conversion
4
conversion 4-bromo-3-yn-1-ols
4
4-bromo-3-yn-1-ols γ-butyrolactones
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!