AI Article Synopsis
- The study aimed to investigate the relationship between CD36 gene variants and the eye condition polypoidal choroidal vasculopathy (PCV) compared to typical neovascular age-related macular degeneration (tAMD).
- Researchers analyzed genetic data from 349 Japanese AMD patients and 198 control individuals, focusing on specific single-nucleotide polymorphisms (SNPs) in the CD36 gene.
- The findings suggested that although no SNPs were linked to PCV directly, significant differences in SNP frequencies and genotypes were observed between PCV and tAMD patients, indicating a potential genetic susceptibility difference between these two conditions.
Article Abstract
Purpose: To clarify the association of cluster of differentiation 36 (CD36) variants with polypoidal choroidal vasculopathy (PCV) and compare them with those in typical neovascular age-related macular degeneration (tAMD).
Methods: We included 349 Japanese AMD patients (210 PCV, 139 tAMD) and 198 age-matched controls. Four tag single-nucleotide polymorphisms (SNPs)-rs10499862, rs3173798, rs3211883, and rs3173800-in the CD36 region were genotyped using the TaqMan assay. Allelic and genotypic frequencies of the SNPs were tested.
Results: Although none of the SNPs tested were associated with PCV, the allelic frequencies of rs3173798 and rs3173800 were significantly different between PCV and tAMD patients. Genotype association analysis demonstrated different associations of these two SNPs between PCV and tAMD in the genotype model. Haplotype analysis revealed that the association of the major haplotype (T-T-T-T) at four selected SNPs in CD36 differed significantly between PCV and tAMD patients.
Conclusions: The CD36 region may be associated with the difference in genetic susceptibility for PCV and tAMD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265175 | PMC |
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