Due to their mechanical design, current wheelchair ergometers cannot simulate the behaviour of a wheelchair propelled on curvilinear paths. This is because they implement a dynamic model of the Wheelchair-user system propelled on Straight Line only (WSL). In this paper, we present a new dynamic model of the Wheelchair-user propelled on Straight and Curvilinear paths (WSC), along with a characterization method based on measurements recorded on the field. Other than measured geometrical constants and kinetic/kinematic data from instrumented wheels, no information about the dynamic parameters such as the system's mass and its moment of inertia are necessary. The accuracy of the new WSC model was compared with the WSL model. To this end, ten subjects propelled an instrumented wheelchair following straight and curvilinear patterns. The recorded kinetics were fed to both models, and their estimated kinematics were compared to the recorded ones. For the curvilinear patterns, the RMS relative error between the estimated and measured rear wheels velocities over a complete push cycle are lower for the WSC model than for the WSL model. Outward wheel: 7.98% (WSC) vs 12.98% (WSL). Inward wheel: 10.76% (WSC) vs 20.73% (WSL).
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http://dx.doi.org/10.1109/ICORR.2011.5975357 | DOI Listing |
Mol Neurobiol
January 2025
Department of Anesthesiology, Yijishan Hospital, First Affiliated Hospital of Wannan Medical College, Wuhu, 241004, China.
Stroke is the second-leading global cause of death. The damage attributed to the immune storm triggered by ischemia-reperfusion injury (IRI) post-stroke is substantial. However, data on the transcriptomic dynamics of pyroptosis in IRI are limited.
View Article and Find Full Text PDFPharmacoeconomics
January 2025
Belgian Health Care Knowledge Centre, Brussels, Belgium.
Background: Forecasting future public pharmaceutical expenditure is a challenge for healthcare payers, particularly owing to the unpredictability of new market introductions and their economic impact. No best-practice forecasting methods have been established so far. The literature distinguishes between the top-down approach, based on historical trends, and the bottom-up approach, using a combination of historical and horizon scanning data.
View Article and Find Full Text PDFMed Biol Eng Comput
January 2025
Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy.
Performing automatic and standardized 4D TEE segmentation and mitral valve analysis is challenging due to the limitations of echocardiography and the scarcity of manually annotated 4D images. This work proposes a semi-supervised training strategy using pseudo labelling for MV segmentation in 4D TEE; it employs a Teacher-Student framework to ensure reliable pseudo-label generation. 120 4D TEE recordings from 60 candidates for MV repair are used.
View Article and Find Full Text PDFJ Chem Inf Model
January 2025
Donostia International Physics Center (DIPC), 20018 Donostia-San Sebastián, Spain.
Desalination of seawater by forward osmosis is a technology potentially able to address the global water scarcity problem. The major challenge limiting its widespread practical application is the design of a draw solute that can be separated from water by an energetically efficient process and then reused for the next cycle. Recent experiments demonstrate that a promising draw solute for forward-osmosis desalination is tetrabutylphosphonium 2,4,6-trimethylbenzenesulfonate ([P][TMBS]).
View Article and Find Full Text PDFJACC Heart Fail
January 2025
Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Data from large-scale, randomized, controlled trials demonstrate that contemporary treatments for heart failure (HF) can substantially improve morbidity and mortality. Despite this, observed outcomes for patients living with HF are poor, and they have not improved over time. The are many potential reasons for this important problem, but inadequate use of optimal medical therapy for patients with HF, an important component of guideline-directed medical therapy, in routine practice is a principal and modifiable contributor.
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