Second near-infrared (NIR) window light (950-1400 nm) is attractive for in vivo fluorescence imaging due to its deep penetration depth in tissues and low tissue autofluorescence. Here we show genetically engineered multifunctional M13 phage can assemble fluorescent single-walled carbon nanotubes (SWNTs) and ligands for targeted fluorescence imaging of tumors. M13-SWNT probe is detectable in deep tissues even at a low dosage of 2 μg/mL and up to 2.5 cm in tissue-like phantoms. Moreover, targeted probes show specific and up to 4-fold improved uptake in prostate specific membrane antigen positive prostate tumors compared to control nontargeted probes. This M13 phage-based second NIR window fluorescence imaging probe has great potential for specific detection and therapy monitoring of hard-to-detect areas.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905603 | PMC |
| http://dx.doi.org/10.1021/nl2031663 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Realization of a Laughlin State of Two Rapidly Rotating Fermions.
Phys Rev Lett
December 2024
Physikalisches Institut der Universität Heidelberg, Im Neuenheimer Feld 226, 69120 Heidelberg, Germany.
We realize a Laughlin state of two rapidly rotating fermionic atoms in an optical tweezer. By utilizing a single atom and spin resolved imaging technique, we sample the Laughlin wave function thereby revealing its distinctive features, including a vortex distribution in the relative motion, correlations in the particles' relative angle, and suppression of the interparticle interactions. Our Letter lays the foundation for atom-by-atom assembly of fractional quantum Hall states in rotating atomic gases.
View Article and Find Full Text PDF12″ Wafer-Scale Mass-Manufactured Metal-Insulator-Metal Reflective Metaholograms by Nanotransfer Printing.
ACS Appl Mater Interfaces
January 2025
Department of Materials Science and Engineering, Korea University, Seoul 02841, Republic of Korea.
The unique characteristics of metasurfaces to precisely control the amplitude, phase, and polarization of light within a thin, flat footprint make them a promising replacement for bulky optical components. However, fabrication methods of conventional metasurfaces have suffered from low throughput and high costs, limiting scalability and practical application. To address these challenges, an advanced fabrication technique is developed by combining deep-ultraviolet argon fluoride photolithography with wafer-scale nanotransfer printing to facilitate the scalable fabrication of metal-insulator-metal structures.
View Article and Find Full Text PDFOptical Coherence Tomography Angiography findings in Syphilitic Outer Retinitis.
Retin Cases Brief Rep
December 2024
Department of Ophthalmology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
Purpose: to report optical coherence tomography angiography findings in syphilitic outer retinopathy, a singular clinical manifestation of ocular syphilis.
Methods: case report.
Results: Multimodal imaging including optical coherence tomography angiography was performed in a patient presenting syphilitic outer retinopathy.
Epstein-Barr Virus-Associated Frosted Branch Angiitis: A Case Report and Brief Review.
Retin Cases Brief Rep
December 2024
Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.
Purpose: To report the clinical presentation, treatment course, and outcome of a case of bilateral frosted branch angiitis (FBA) and neuroretinitis associated with acute Epstein-Barr virus (EBV) infection in a pediatric patient with Turner Syndrome.
Methods: Case report with multimodal ocular imaging and extensive systemic workup.
Results: A 16-year-old female with Turner syndrome presented with acute bilateral vision loss, hearing loss, and ataxia.
Zero-Crosstalk Tumor-Targeting Ratiometric Near-Infrared γ-Glutamyltranspeptidase Probe for Fluorescent-Guided Surgical Resection of Orthotopic Hepatic Tumor.
Anal Chem
January 2025
Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, Hunan Provincial University Key Laboratory for Environmental and Ecological Health, College of Chemistry, Xiangtan University, Xiangtan 411105, P.R. China.
The challenge of "false positive" signals significantly complicates tumor localization and surgical resection, which are pivotal for successful tumor surgeries. Therefore, the development of a method for preoperative tumor localization and intraoperative margin determination holds considerable promise for improving surgical outcomes. In this study, a zero-crosstalk ratiometric tumor-targeting near-infrared (NIR) fluorescent probe was developed for precise cancer diagnosis and intraoperative navigation via NIR fluorescence imaging.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!