Advances in tissue engineering have permitted the three-dimensional (3D) reconstruction of human oral mucosa for various in vivo and in vitro applications. Tissue-engineered oral mucosa have been further optimized in recent years for clinical applications as a suitable graft material for intra-oral and extra-oral repair and treatment of soft-tissue defects. Novel 3D in vitro models of oral diseases such as cancer, Candida, and bacterial invasion have been developed as alternatives to animal models for investigation of disease phenomena, their progression, and treatment, including evaluation of drug delivery systems. The introduction of 3D oral mucosal reconstructs has had a significant impact on the approaches to biocompatibility evaluation of dental materials and oral healthcare products as well as the study of implant-soft tissue interfaces. This review article discusses the recent advances in tissue engineering and applications of tissue-engineered human oral mucosa.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1177/0022034511435702 | DOI Listing |
J Stomatol Oral Maxillofac Surg
January 2025
Professor, Department of Oral, Dental and Maxillofacial Radiology, Faculty of Dentistry, Ataturk University, Erzurum, 25240, Turkiye.
Objectives: This study aimed to evaluate with ultrasonography (US) the location of GPF, the course of the GPA, and to measure palatal fibromucosa thickness.
Materials And Methods: This in vivo experiment was conducted on a group of healthy, young Turkish subjects. Using the US, the localization of the GPF, its diameter and opening type, maximum flow velocity (Vmax) and collateral branches (CB) of the GPA, and the thickness of the palatine mucosa were evaluated.
J Am Acad Dermatol
January 2025
Mayo Clinic Arizona, Department of Dermatology, Scottsdale, AZ, USA.
Many dermatologic and systemic disorders present with oral manifestations. Early diagnosis and treatment can improve patient outcomes. Medical, dermatology, and dentistry training in disorders of the oral mucosa is significantly lacking and has created a practice gap in diagnosing and treating oral mucosal disorders.
View Article and Find Full Text PDFCureus
December 2024
Medical Speciality Department, Niger Maradi Reference Hospital, Maradi, NER.
A Zenker's diverticulum (ZD) is an acquired hernia of the mucosa and submucosa at the pharyngoesophageal junction dorsally through Killian's triangle, considered a zone of weakness. The authors report their experience in the management of a case of a ZD with oral externalization following coughing. Surgery made by a multidisciplinary team consisted first of resection of the edematous exteriorized portion of the diverticulum.
View Article and Find Full Text PDFInt J Nanomedicine
January 2025
Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
Purpose: Dimethyl fumarate (DMF), the first-line oral therapy for relapsing-remitting multiple sclerosis, is rapidly metabolized into monomethyl fumarate. The DMF oral administration provokes gastrointestinal discomfort causing treatment withdrawal. The present study aimed to develop an innovative formulation for DMF nasal administration.
View Article and Find Full Text PDFClin Case Rep
January 2025
Department of Oral and Maxillofacial Pathology, School of Dentistry Shahid Beheshti University of Medical Sciences Tehran Iran.
Extramedullary plasmacytomas (EMP) are uncommon solitary tumors composed of neoplastic plasma cells occurring outside the bone. These lesions are of clinical significance due to their potential progression to multiple myeloma (MM), a more systemic and serious plasma cell malignancy. Although EMPs primarily arise in the head and neck region, cases involving the oral cavity are particularly rare.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!