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Cystic Neutrophilic Granulomatous Mastitis: Imaging Features With Histopathologic Correlation.
J Breast Imaging
December 2024
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Cystic neutrophilic granulomatous mastitis (CNGM) is a rare type of granulomatous lobular mastitis (GLM) with a distinct histologic pattern characterized on histopathology by clear lipid vacuoles lined by peripheral neutrophils ("suppurative lipogranulomas"), often containing gram-positive bacilli and strongly associated with Corynebacterial infection (in particular, Corynebacterium kroppenstedtii). Cystic neutrophilic granulomatous mastitis has a distinct histopathologic appearance, but the imaging appearance is less well described and has been limited to case reports and small case series published primarily in pathology literature. Mammographic findings of CNGM include focal asymmetry, skin thickening, and irregular or oval masses.
View Article and Find Full Text PDFAdipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancer.
Breast
November 2024
Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium. Electronic address:
Background: The adipose tissue may serve as a source of energy supporting cancer growth and metastasis. Our understanding of the adipocytes which compose the adipose tissue in different anatomical locations of the body as well as potential microscopic tumor infiltration in patients with metastatic breast cancer remains limited. This study therefore investigates regional variations in adipocyte size and adipose tissue tumor infiltration in patients with metastatic breast cancer.
View Article and Find Full Text PDFA Retrospective Study of the Histopathological Spectrum of Erythema Nodosum Leprosum.
Indian Dermatol Online J
August 2024
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Article Synopsis
- Recent studies on the histopathology of erythema nodosum leprosum (ENL) are lacking, which this research aims to address by describing its histopathological characteristics.
- A total of 125 biopsies were analyzed, revealing various infiltration patterns with the most common being a well-defined dermal infiltrate, observed in over half of the samples, along with varying degrees of subcutaneous tissue involvement.
- The findings highlighted the presence of immune cells like neutrophils and foamy histiocytes, with some cases showing acid-fast bacilli using specific staining techniques, although limitations included the retrospective nature of the study which hindered comparisons with clinical characteristics.
Periorbital Intravenous Lobular Pyogenic Granulomas: A Case Report and Literature Review of This Peculiar Pathology.
Ophthalmic Plast Reconstr Surg
January 2025
Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alberta, Canada.
Article Synopsis
- Intravenous lobular pyogenic granuloma (ILPG) is a rare condition affecting the periorbital area, characterized by palpable subcutaneous nodules, and this study focuses on its clinical presentation and pathology.
- A case study of a 42-year-old male diagnosed with ILPG through immunohistochemistry was presented, alongside a literature review that identified 6 other similar cases treated with local excision.
- Histopathological analysis showed ILPG to consist of capillary structures and a strong reaction to specific markers, with low recurrence rates after surgical treatment, suggesting its relevance in diagnosing periocular masses.
Superficial Anaplastic Lymphoma Kinase-Rearranged Myxoid Spindle Cell Neoplasm in the Buttock: A Case Report.
J Pers Med
August 2024
Department of Pathology, Konyang University Hospital, College of Medicine, University of Konyang, Myunggok Medical Research Institute, Daejeon 35365, Republic of Korea.
Anaplastic lymphoma kinase (ALK) is detected in both normal and oncological developmental tissues. Among ALK-related tumors, superficial ALK-rearranged myxoid spindle cell neoplasm (SAMS) is a rare, soft tissue tumor characterized by the immunophenotypical co-expression of CD34 and S100. Here, we describe a patient with this rare tumor and outline its clinical and radiological characteristics.
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