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Host and pathogen factors that influence variability of Mycobacterium tuberculosis lipid body content in sputum from patients with tuberculosis: an observational study.
Lancet Microbe
September 2024
Department of Respiratory Sciences, University of Leicester, Leicester, UK; Leicester Tuberculosis Research Group, University of Leicester, Leicester, UK; National Institute for Health and Care Research Leicester Biomedical Research Centre, Leicester, UK. Electronic address:
Background: High proportions of Mycobacterium tuberculosis cells in sputum containing triacylglycerol-rich lipid bodies have been shown to be associated with treatment failure or relapse following antituberculous chemotherapy. Although lipid body determination is a potential biomarker for supporting clinical trial and treatment decisions, factors influencing variability in sputum frequencies of lipid body-positive (%LB) M tuberculosis in patients are unknown. We aimed to test our hypothesis that exposure to host-generated NO and M tuberculosis strains are factors associated with differences in sputum %LB.
View Article and Find Full Text PDFAge and sex influence antibody profiles associated with tuberculosis progression.
Nat Microbiol
June 2024
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Antibody features vary with tuberculosis (TB) disease state. Whether clinical variables, such as age or sex, influence associations between Mycobacterium tuberculosis-specific antibody responses and disease state is not well explored. Here we profiled Mycobacterium tuberculosis-specific antibody responses in 140 TB-exposed South African individuals from the Adolescent Cohort Study.
View Article and Find Full Text PDFImpaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity.
Clin Transl Med
September 2023
Department of Infection Biology and TB Centre, London School of Hygiene & Tropical Medicine, London, UK.
Article Synopsis
- People with diabetes are more susceptible to tuberculosis (TB), showing higher inflammation and lower immune responses that may lead to worse treatment outcomes.
- A study tracked the gene expression of TB patients with and without diabetes during treatment to understand how these differences evolve over time.
- Results indicated that TB-DM patients exhibited persistent and heightened inflammatory responses throughout treatment, suggesting that their immune system struggles to adjust compared to those without diabetes.
Field evaluation of a point-of-care triage test for active tuberculosis (TriageTB).
BMC Infect Dis
July 2023
Stellenbosch University, Cape Town, South Africa.
Background: To improve tuberculosis (TB) diagnosis, the World Health Organisation (WHO) has called for a non-sputum based triage test to focus TB testing on people with a high likelihood of having active pulmonary tuberculosis (TB). Various host or pathogen biomarker-based testing devices are in design stage and require validity assessment. Host biomarkers have shown promise to accurately rule out active TB, but further research is required to determine generalisability.
View Article and Find Full Text PDFT cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection.
Nat Med
January 2023
South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Antigen-specific, MHC-restricted αβ T cells are necessary for protective immunity against Mycobacterium tuberculosis, but the ability to broadly study these responses has been limited. In the present study, we used single-cell and bulk T cell receptor (TCR) sequencing and the GLIPH2 algorithm to analyze M. tuberculosis-specific sequences in two longitudinal cohorts, comprising 166 individuals with M.
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