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Costimulation blockade: the next generation.
Curr Opin Organ Transplant
January 2025
Division of Nephrology, Virginia Commonwealth University, Richmond, Virginia, USA.
Purpose Of The Review: Calcineurin inhibitors (CNIs) are central to immunosuppression in kidney transplantation (KT), improving short-term outcomes but falling short in enhancing long-term outcomes due to cardiovascular, metabolic, and renal complications. Belatacept, an FDA-approved costimulation blocker, offers a less toxic alternative to CNIs but is limited by its intravenous administration and reduced efficacy in high-immunological-risk patients.
Recent Findings: Emerging therapies target more specific pathways to improve efficacy and accessibility.
Reevaluating Gender Disparities in Academic Productivity in Plastic Surgery: Women Produce Impactful Research, Yet Their Output Falls Short.
J Surg Res
January 2025
Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University, Palo Alto, California.
A novel interval sparse evolutionary algorithm for efficient spectral variable selection.
Anal Chim Acta
March 2025
School of Automation, Central South University, 410083, Changsha, China. Electronic address:
In spectral analysis, selecting the right spectral variables is crucial for effective modeling. It reduces data dimensionality, removes irrelevant wavelength points, and improves both the generalization ability and computational efficiency of the model. However, the number of available samples often falls short of the total possible combinations of wavelengths, making variable selection a non-deterministic polynomial-time (NP) hard optimization problem.
View Article and Find Full Text PDFBots in white coats: are large language models the future of patient education? a multi-center cross-sectional analysis.
Int J Surg
January 2025
Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Germany.
Objectives: Every year, around 300 million surgeries are conducted worldwide, with an estimated 4.2 million deaths occurring within 30 days after surgery. Adequate patient education is crucial, but often falls short due to the stress patients experience before surgery.
View Article and Find Full Text PDFIn space-based gravitational wave detection, establishing ultra-long-distance and ultra-high-precision laser links between satellites is achieved through the laser acquisition and tracking system. The laser spot centroid positioning method, which offers low computational complexity and strong adaptability to beam shape, is currently the core measurement method during the laser acquisition phase. However, due to various interference factors encountered in practical tests, this algorithm often falls short of meeting the extremely high requirements.
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