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Adiponectin and leptin systems in human endometrium during window of implantation. | LitMetric

Adiponectin and leptin systems in human endometrium during window of implantation.

Fertil Steril

Service de Biochimie et Biologie Moléculaire, Unité Propre de Recherche et de l'Enseignement Supérieur- Equipe d'Accueil 2493, Pôle de Recherche et de l'Enseignement Supérieur Universud Paris, Centre Hospitalier de Poissy-Saint Germain, Poissy Cedex, France.

Published: March 2012

AI Article Synopsis

  • The study aimed to compare the expression of adiponectin, leptin, and their receptors in the endometrial tissue of fertile women versus those experiencing unexplained recurrent implantation failure (IF) during the implantation window.
  • Results showed lower leptin levels but higher leptin receptor expression in women with IF, while adiponectin levels were similar in both groups, but its receptors showed reduced expression in those with IF.
  • The findings suggest that changes in leptin and adiponectin receptor expression might play a role in uterine receptivity issues associated with IF, indicating potential new targets for predicting implantation failure.

Article Abstract

Objective: To measure the expression of adiponectin, leptin, and their respective receptors in the human endometria of fertile women compared with women with unexplained recurrent implantation failure (IF) during the window of implantation.

Design: Controlled, prospective, clinical study.

Setting: Teaching hospital and university research laboratory.

Patient(s): Thirty-one endometrial biopsies from women with IF and 19 fertile controls.

Intervention(s): Human endometrial biopsies.

Main Outcome Measure(s): Gene and protein expression of endometrial biopsies.

Result(s): Endometrial leptin expression was significantly lower in the IF group compared with fertile women. In contrast, leptin receptor (Ob-R) expression was higher in endometria of women with IF. Concerning the adiponectin system, adiponectin was expressed to the same extent in both groups. Conversely, the expression of its two receptors, AdipoR1 and AdipoR2, was reduced in endometria of women with IF compared with fertile women.

Conclusion(s): Although progesterone resistance seems to be a common state of the endometrium in some human reproductive disorders, such as endometriosis or polycystic ovary syndrome, modification in leptin endometrial expression seems to be specific to IF. These results strongly suggest that changes in Ob-R and AdipoR expression profiles [1] should be implicated in the development of uterine receptivity, and [2] may therefore be potential new targets for prediction of IF.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fertnstert.2011.12.042DOI Listing

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