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Anti-angiogenic properties of ADAMTS-4 in vitro. | LitMetric

Anti-angiogenic properties of ADAMTS-4 in vitro.

Int J Exp Pathol

Academic Unit of Molecular Medicine and Rheumatology, University of Sheffield Medical School, Sheffield, UK.

Published: February 2012

Angiogenesis is an indispensable mechanism in development and in many pathologies, including cancer, synovitis and aberrant wound healing. Many angiogenic stimulators and inhibitors have been investigated, and some have progressed to the clinic. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a group of multifunctional proteinases. ADAMTS-1 and ADAMTS-8 have been reported to be anti-angiogenic. Here, we provide evidence that ADAMTS-4, like ADAMTS-1, is expressed by endothelial cells and binds to vascular endothelial groth factor (VEGF). Moreover, ADAMTS-4 inhibited human dermal microvascular endothelial cells (HuDMEC) VEGF-stimulated VEGF receptor (R) R2 phosphorylation, differentiation and migration, suggesting that ADAMTS-4 may be a novel anti-angiogenic molecule.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311023PMC
http://dx.doi.org/10.1111/j.1365-2613.2011.00802.xDOI Listing

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