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http://dx.doi.org/10.1590/s0101-28002010000500003 | DOI Listing |
BMC Med
January 2025
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Background: Since older adults spend significant time in their neighborhood environment, environmental factors such as neighborhood socioeconomic disadvantage, high racial segregation, low healthy food availability, low access to recreation, and minimal social engagement may have adverse effects on cognitive function and increase susceptibility to dementia. DNA methylation, which is associated with neighborhood characteristics as well as cognitive function and white matter hyperintensity (WMH), may act as a mediator between neighborhood characteristics and neurocognitive outcomes.
Methods: In this study, we examined whether DNA methylation in peripheral blood leukocytes mediates the relationship between neighborhood characteristics and cognitive function (N = 542) or WMH (N = 466) in older African American (AA) participants without preliminary evidence of dementia from the Genetic Epidemiology Network of Arteriopathy (GENOA).
Sci Rep
January 2025
Babson College, Wellesley, USA.
The COVID-19 pandemic has been a time of great intensity that exposed many existing inequities in facing this global threat. Building on Galtung's conceptualization of positive peace as the absence of structural violence and institutionalized inequality, we study the gendered effect of the COVID-19 pandemic on reported subjective wellbeing (SWB) in four countries in the Middle East. Data from mobile phone panel surveys, with a total sample of 12,614 observations collected during this critical juncture, show that women consistently reported a lower level of SWB than men in all four countries.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Preventive Medicine, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia.
Background: Despite the rising prevalence of common mental symptoms, information is scarce on how health workers make sense of symptoms of mental disorders and perceive a link with inadequate water, sanitation, and hygiene (WASH) as work stressors to understand causation and produce useful knowledge for policy and professionals. Therefore, this study aimed to explore how health workers perceive the link between inadequate WASH and common mental symptoms (CMSs) at hospitals in central and southern Ethiopian regions.
Methods: We used an interpretive and descriptive phenomenological design guided by theoretical frameworks.
Drug Saf
January 2025
Pfizer (Worldwide Medical & Safety), New York, NY, USA.
J Am Med Inform Assoc
January 2025
Coordinating Center, Observational Health Data Science and Informatics, New York City, NY 10032, United States.
Objective: Propose a framework to empirically evaluate and report validity of findings from observational studies using pre-specified objective diagnostics, increasing trust in real-world evidence (RWE).
Materials And Methods: The framework employs objective diagnostic measures to assess the appropriateness of study designs, analytic assumptions, and threats to validity in generating reliable evidence addressing causal questions. Diagnostic evaluations should be interpreted before the unblinding of study results or, alternatively, only unblind results from analyses that pass pre-specified thresholds.
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