CTRP family: linking immunity to metabolism.

Trends Endocrinol Metab

Department of Internal Medicine I, Regensburg University Medical Center, D-93042 Regensburg, Germany.

Published: April 2012

It is well known that infectious and inflammatory diseases such as sepsis and severe inflammatory response syndrome are accompanied by metabolic alterations such as insulin resistance. Conversely, metabolic diseases such as visceral obesity and type 2 diabetes are characterized by high levels of proinflammatory cytokines. Metabolism and immunity are linked by proteins of dual function. Adiponectin, a member of the C1q/TNF-related protein (CTRP) family, has attracted much interest because of its anti-inflammatory and insulin-sensitizing effects. To date, 15 additional CTRP family members have been identified that might also play a role in metabolism and immunity. This review focuses on the biochemistry and pleiotropic physiological functions of CTRPs as new molecular mediators connecting inflammatory and metabolic diseases.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tem.2011.12.003DOI Listing

Publication Analysis

Top Keywords

ctrp family
12
metabolic diseases
8
metabolism immunity
8
family linking
4
linking immunity
4
immunity metabolism
4
metabolism well
4
well infectious
4
infectious inflammatory
4
inflammatory diseases
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!