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Long-term trends in the incidence of male breast cancer and nomogram for predicting survival in male breast cancer patients: a population-based epidemiologic study.
Sci Rep
January 2025
Department of Thoracic Surgery, Henan Provincial Chest Hospital (Chest Hospital of Zhengzhou University, Room 1, Weiwu Road, Zhengzhou, 450000, Henan, China.
Male breast cancer (MBC) is rare, and due to the absence of male-specific screening programs, many patients are diagnosed at advanced stages and older ages. This study aims to analyze the long-term trend of MBC incidence and develop a competing risk model to improve survival rates. MBC data from the Surveillance, Epidemiology, and End Results (SEER) database (1975-2019) were analyzed using the Age-Period-Cohort (APC) model to examine trends in age, period, and birth cohort effects of MBC incidence.
View Article and Find Full Text PDFPostmarketing adverse events of tamoxifen in male and female patients with breast cancer.
Int J Cancer
February 2025
Department of Pharmacy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China.
Tamoxifen (TAM), a selective estrogen receptor (ER) modulator, has received approval for use in patients with breast cancer (BC) exhibiting positive ER expression. Given the widespread clinical use of TAM, a comprehensive real-world study of its adverse events (AEs) is warranted. The database for analysis, sourced from the Food and Drug Administration Adverse Event Reporting System (FAERS), covers the period from the first quarter of 2014 to the third quarter of 2023.
View Article and Find Full Text PDFMutant mice lacking alternatively spliced p53 isoforms unveil as a male-specific prognostic factor in Myc-driven B-cell lymphomas.
Elife
September 2024
Genetics of Tumor Suppression, Institut Curie, Paris, France.
The gene encodes several isoforms of elusive biological significance. Here, we show that mice lacking the alternatively spliced (AS) exon, thereby expressing the canonical p53 protein but not isoforms with the AS C-terminus, have unexpectedly lost a male-specific protection against Myc-induced B-cell lymphomas. Lymphomagenesis was delayed in males compared to males, but also compared to and females.
View Article and Find Full Text PDFThe Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male-But Not Female-Rats to Enhance Short-Term Memory.
J Neurosci
September 2024
Department of Psychology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
Acetylation of histone proteins by histone acetyltransferases (HATs), and the resultant change in gene expression, is a well-established mechanism necessary for long-term memory (LTM) consolidation, which is not required for short-term memory (STM). However, we previously demonstrated that the HAT p300/CBP-associated factor (PCAF) also influences hippocampus (HPC)-dependent STM in male rats. In addition to their epigenetic activity, HATs acetylate nonhistone proteins involved in nongenomic cellular processes, such as estrogen receptors (ERs).
View Article and Find Full Text PDFTNFR1/p38αMAPK signaling in Nex + supraspinal neurons regulates estrogen-dependent chronic neuropathic pain.
Brain Behav Immun
July 2024
Department of Anatomy and Cell Biology, The George Washington University School of Medicine and Health Sciences, Ross Hall, 2300 I (Eye) St NW, Rm.530A, Washington, D.C 20052, USA. Electronic address:
Upregulation of soluble tumor necrosis factor (sTNF) cytokine signaling through TNF receptor 1 (TNFR1) and subsequent neuronal hyperexcitability are observed in both animal models and human chronic neuropathic pain (CNP). Previously, we have shown that estrogen modulates sTNF/TNFR1 signaling in CNP, which may contribute to female prevalence of CNP. The estrogen-dependent role of TNFR1-mediated supraspinal neuronal circuitry in CNP remains unknown.
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