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Conventional (bone-type) giant cell tumor of the larynx: the first case with proven H3-3A: c.103G >T (p.Gly35Trp) mutation.
Virchows Arch
November 2024
Institute of Pathology, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
This report documents the first case of a conventional (bone-type) giant cell tumor of the larynx, in which the diagnosis was confirmed by molecular genetic analysis. A 50-year-old non-smoking man experienced progressive hoarseness lasting for 3 months. Imaging showed a 40-mm tumor arising from the right thyroid cartilage.
View Article and Find Full Text PDFFine-needle aspiration and effusion cytology of thoracic SMARCA4-deficient undifferentiated tumor and SMARCA4-deficient non-small cell lung carcinoma: A multi-institutional experience with 27 patients.
Cancer Cytopathol
November 2024
Department of Pathology, Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Article Synopsis
An unusual pattern of endometrial involvement: superficial spreading squamous cell carcinoma of the cervix.
Front Oncol
October 2024
Department of Pathology, Guangyuan Central Hospital, Guangyuan, China.
Article Synopsis
- * The study reports on 15 cases of superficial spreading SCC in postmenopausal and perimenopausal women, with vaginal bleeding as a prominent symptom, all patients being HPV 16 positive.
- * Findings indicate that SCC often presents as high-grade lesions within the endometrial tissue, with varying degrees of differentiation and specific biomarkers, highlighting the complexity of this uncommon spread and the need for further management guidelines.
Pilomatrix-like breast carcinoma: A mammary analog of pilomatrix-like high-grade endometrioid carcinoma (PiMHEC).
Am J Clin Pathol
October 2024
Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, US.
Article Synopsis
- - This study presents the first recognized case of triple-negative breast carcinoma (TNBC) that has a PiMHEC-like phenotype, characterized by certain defining features such as high-grade morphology and specific mutations.
- - The tumor was found adjacent to a HER2-positive invasive ductal carcinoma, showing different marker expressions and mutations, suggesting a clonal relationship between the two components.
- - Overall, the findings indicate that a PiMHEC-like TNBC can develop from conventional invasive ductal carcinoma, potentially explaining a lack of response to typical chemotherapy treatments.
[Clinicopathological and molecular characteristics of microsecretory adenocarcinoma in salivary gland].
Zhonghua Bing Li Xue Za Zhi
October 2024
Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.
To investigate the clinicopathological, immunohistochemical, and molecular genetic characteristics of microsecretory adenocarcinoma (MSA) of the salivary gland, and to improve the understanding of this rare tumor. Cases originally diagnosed as MSA at the Department of Oral Pathology, the Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine were retrospectively collected. The cases of polymorphous adenocarcinoma and adenocarcinoma, not otherwise specified from January 2000 to January 2020 were reviewed to identify potential misdiagnosed MSA cases.
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