Five cases of intestinal toxemia botulism in adults were identified within an 18-month period in or near Toronto, Ontario, Canada. We describe findings for 3 of the 5 case-patients. Clinical samples contained Clostridium botulinum spores and botulinum neurotoxins (types A and B) for extended periods (range 41-61 days), indicative of intestinal toxemia botulism. Patients' clinical signs improved with supportive care and administration of botulinum antitoxin. Peanut butter from the residence of 1 case-patient yielded C. botulinum type A, which corresponded with type A spores found in the patient's feces. The food and clinical isolates from this case-patient could not be distinguished by pulsed-field gel electrophoresis. Two of the case-patients had Crohn disease and had undergone previous bowel surgery, which may have contributed to infection with C. botulinum. These cases reinforce the view that an underlying gastrointestinal condition is a risk factor for adult intestinal toxemia botulism.
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| http://dx.doi.org/10.3201/eid1801.110533 | DOI Listing |
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Article Synopsis
- Endotoxemia is linked to various diseases, and the gut microbiota plays a crucial role as it acts as a major reservoir of endotoxins in the body.
- Dysbiosis in the gut microbiota can lead to increased intestinal permeability and bacterial translocation, contributing to endotoxemia.
- The Mediterranean diet is highlighted as beneficial for gut health, potentially regulating the microbiota and supporting intestinal barrier function to mitigate endotoxemia.
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