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Pancreatitis and the Risk of Developing Gastric Neuromuscular Dysfunction.
Clin Transl Gastroenterol
February 2023
Center for Neurointestinal Health, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Introduction: Most gastroparesis and functional dyspepsia cases (collectively, gastric neuromuscular dysfunction [GND]) remain idiopathic. It is believed that some idiopathic cases of GND may be triggered by an inflammatory insult to the gastrointestinal tract. We theorized that the profound foregut inflammation induced by pancreatitis could result in increased risk of GND.
View Article and Find Full Text PDFAcute Sensory and Autonomic Neuronopathy: A Devastating Disorder Affecting Sensory and Autonomic Ganglia.
Semin Neurol
October 2020
Department of Neurology, Dysautonomia Center, New York University School of Medicine, New York, New York.
Acute-onset and severe sensory and autonomic deficits with no motor dysfunction, typically preceded by a febrile illness, with poor recovery, and often fatal outcome are the hallmark features of acute sensory and autonomic neuronopathy (ASANN). Pathologically and electrophysiologically, ASANN is characterized by an extensive ganglionopathy affecting sensory and autonomic ganglia with preservation of motor neurons. Consequently, patients, usually children or young adult, develop acute-onset profound widespread loss of all sensory modalities resulting in automutilations, as well as autonomic failure causing neurogenic orthostatic hypotension, neurogenic underactive bladder, and gastroparesis and constipation.
View Article and Find Full Text PDFAutonomic symptoms affect most patients with Parkinson's disease (PD) and often have a profound impact on their prognosis. Symptoms include orthostatic hypotension, gastroparesis, constipation, excessive sweating, and sexual dysfunction, however, these symptoms are frequently unrecognised by clinicians and remain untreated. The mechanism of autonomic dysfunction is attributed to the involvement of the central and peripheral postganglionic nervous system.
View Article and Find Full Text PDFProfound opiate toxicity in gastroparesis following therapeutic dose.
BMJ Case Rep
May 2016
Department of Accident & Emergency, Broomfield Hospital, Chelmsford, UK.
Gastroparesis is defined by the presence of delayed gastric emptying without mechanical obstruction. Patients may present with severe discomfort that can mimic an acute abdomen including abdominal pain, vomiting, nausea, bloating, fullness and early satiety. The prevalence of gastroparesis is estimated at 24 per 100 000 and women are more commonly affected than men.
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