The development, implementation and use of computer-based medical decision support systems (MDSS) based on pattern recognition techniques holds the promise of substantially improving the quality of medical practice in diagnostic and prognostic tasks. In this study, the core of a decision support system for brain tumour classification from magnetic resonance spectroscopy (MRS) data is presented. It combines data pre-processing using Gaussian decomposition, dimensionality reduction using moving window with variance analysis, and classification using artificial neural networks (ANN). This combination of techniques is shown to yield high diagnostic classification accuracy in problems concerning diverse brain tumour pathologies, some of which have received little attention in the literature.
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http://dx.doi.org/10.1109/IEMBS.2011.6091366 | DOI Listing |
Cureus
January 2025
Anesthesiology, Universidad Abierta Interamericana, Buenos Aires, ARG.
The differentiation between benign and malignant brain lesions remains a fundamental challenge in modern neuroimaging. This case highlights a rare presentation of ectatic Virchow-Robin spaces (VRS), which mimicked tumefactive brain lesions and required a comprehensive diagnostic evaluation to exclude neoplastic, infectious, and inflammatory processes. A 37-year-old female presented with progressive headache, cognitive impairment, and facial pain.
View Article and Find Full Text PDFJ Pharm Anal
December 2024
School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, China.
Reactive oxygen species (ROS)-mediated anticancer modalities, which disturb the redox balance of cancer cells through multi-pathway simulations, hold great promise for effective cancer management. Among these, cooperative physical and biochemical activation strategies have attracted increasing attention because of their spatiotemporal controllability, low toxicity, and high therapeutic efficacy. Herein, we demonstrate a nanogel complex as a multilevel ROS-producing system by integrating chloroperoxidase (CPO) into gold nanorod (AuNR)-based nanogels (ANGs) for cascade-amplifying photothermal-enzymatic synergistic tumor therapy.
View Article and Find Full Text PDFBrain Behav Immun Health
February 2025
Institute of Maternal and Child Medicine, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, China.
Purpose: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder increasingly recognized for its strong association with chronic inflammation. Adipose tissue functions as an endocrine organ and can secrete inflammatory cytokines to mediate inflammation. However, its involvement in ASD-related inflammation remains unclear.
View Article and Find Full Text PDFBioelectromagnetics
January 2025
Department of Biophysics, Faculty of Medicine, Gazi University, Ankara, Turkey.
The widespread use of wireless communication technologies has increased human exposure to radiofrequency electromagnetic fields (RF-EMFs). Considering the brain's close proximity to mobile phones and its entirely electrical transmission network, it emerges as the organ most profoundly impacted by the RF field. This study aims to investigate the potential effects of RF radiation on cell viability, apoptosis, and gene expressions in glioblastoma cells (U118-MG) at different exposure times (1, 24, and 48 h).
View Article and Find Full Text PDFCancer Res
January 2025
Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Mouse models that faithfully represent the biology of human brain tumors are critical tools for unraveling the underlying tumor biology and screening for potential precision therapies. This is especially true of rare tumor types, many of which have correspondingly few xenograft or cell lines available. Although our understanding of the specific biological pathways driving cancer has improved significantly, identifying the appropriate progenitor populations to drive oncogenic processes represents a significant barrier to efficient mouse model production.
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