This paper presents the analysis of the autonomic nervous system (ANS) control and cardiac baroreflex sensitivity in patients undergoing general anesthesia for major surgery, with the goal of evaluating the effects of anesthesia bolus induction with propofol on autonomic control of heart rate (HR) and arterial blood pressure (ABP). The increase in baroreflex gain in the LF band observed through two different methods hints at the fact that the baroreflex may increase heart period (HP) following a transient ABP decrease, but its response displays a larger amplitude, to compensate for the blunting of the sympathetic action on heart rate and vascular resistance.
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http://dx.doi.org/10.1109/IEMBS.2011.6090767 | DOI Listing |
Alzheimers Dement
December 2024
Erasmus University Medical Center, Rotterdam, Zuid-Holland, Netherlands.
Background: Hypertension is an important modifiable risk factor for dementia, but the role of blood pressure (BP) in the development of dementia is not fully understood. Emerging data links increased BP variability and abnormal BP dynamics to dementia risk, but the relationship between baroreflex sensitivity (BRS), a fundamental physiological mechanism for maintaining stable BP, and dementia risk is unknown.
Methods: We investigated the association of BRS with the risk of dementia in community-based older adults from the Rotterdam Study in the Netherlands.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Autonomic dysfunction and depression are among the most common causes of disability in high-income countries and depression has been associated with deficits in various cognitive domains. The degree to which depression associates with autonomic function and modifies risk for Alzheimer's disease (AD) in older adults is unknown. We investigated the association between depression status and autonomic function measures in 398 participants enrolled in the U.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Obesity is associated with adverse changes in the structure and function of both the brain and the vasculature and may modify risk for Alzheimer's disease (AD). However, the degree to which excess total and central adiposity contribute to overall disease burden in late-life is unclear. We investigated baseline associations between obesity, AD-related pathology, and neurovascular health in 255 participants enrolled in the U.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Sleep disorders have been associated with cognitive impairment and dementia risk. Measures of autonomic function including baroreflex sensitivity (BRS) and heart rate variability (HRV) have also been associated with sleep quality. The extent to which sleep disorders are linked to autonomic function and alter the risk of Alzheimer's disease (AD) in older adults remains unclear.
View Article and Find Full Text PDFFront Neurol
December 2024
Center for Data Science, Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, United States.
Background: Traumatic brain injury (TBI) disrupts normal brain tissue and functions, leading to high mortality and disability. Severe TBI (sTBI) causes prolonged cognitive, functional, and multi-organ dysfunction. Dysfunction of the autonomic nervous system (ANS) after sTBI can induce abnormalities in multiple organ systems, contributing to cardiovascular dysregulation and increased mortality.
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