This paper presents the preliminary results of a study to determine dorsolateral prefrontal cortex sensitivity to rTMS stimulation presented at clinically accepted amplitudes, frequencies and locations. A specially developed EEG system with 10-20 electrode locations was used to record the short latency magnetically evoked potentials. Sixteen normal subjects were stimulated using 10 Hz for the left hemisphere and 1 Hz for the right. The evoked potentials recorded for left sided stimulation were significantly larger than for the right sided stimulation. Further, the stimulation energies, though within the range used clinically for the treatment of depression were insufficient to excite evoked potentials in several subjects.
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http://dx.doi.org/10.1109/IEMBS.2011.6090562 | DOI Listing |
Cerebellum
January 2025
Department of Neurology, Kailuan General Hospital, No. 57 Xinhua East Road, Lubei District, Tangshan City, 063000, Hebei Province, China.
This study aims to evaluate cognitive impairments in patients with acute cerebellar infarction using event-related potentials (ERP) and electrophysiological source imaging (ESI). Thirty patients with acute cerebellar infarction and 32 healthy volunteers were selected. Cognitive potentials were recorded and measured using a visual Oddball paradigm.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Miami, Miami, FL, USA.
Background: Exposures to hazardous noise causes irreversible injury to the structures of the inner ear, leading to changes in hearing and balance function with strong links to age-related cognitive impairment. While the role of noise-induced hearing loss in long-term health consequences, such as progression or development of Alzheimer's Disease (AD) has been suggested, the underlying mechanisms and behavioral and cognitive outcomes or therapeutic solutions to mitigate these changes remain understudied. This study aimed to characterize the association between blast exposure, hearing loss, and the progression of AD pathology, and determine the underlying mechanisms.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Johns Hopkins University, Baltimore, MD, USA.
Background: Alzheimer's disease is a progressive form of dementia where cognitive capacities deteriorate due to neurodegeneration. Interestingly, Alzheimer's patients exhibit cognitive fluctuations during all stages of the disease. Though it is thought that contextual factors are critical for unlocking these hidden memories, understanding the neural basis of cognitive fluctuations has been hampered due to the lack of behavioral approaches to dissociate memories from contextual-performance.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Background: The study of the involvement of the cerebellum in learning and memory has become one of the recent hot topics in the field of cognitive neuroscience. Transcranial magnetic stimulation (TMS) of the cerebellum has gained increasing interest in the treatment of cognition-related disorders, making it necessary to determine the optimal parameters for cerebellar TMS. In this study, we aim to explore the effects of different frequencies of cerebellar repetitive TMS (rTMS) on working memory regulation and the associated electrophysiological changes.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
VA Boston Healthcare System, Jamaica Plain, MA, USA.
Background: In Alzheimer's disease and related dementias (ADRD), memory deficits as assessed through neuropsychological testing and self-report are often defined by instances of forgetting. However, the presence of false memories (e.g.
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