Heterogeneity in the electrical action potential (AP) properties can provide a substrate for atrial arrhythmias, especially at rapid pacing rates. In order to quantify such substrates, we develop a family of detailed AP models for canine atrial cells. An existing model for the canine right atrial (RA) myocyte was modified based on electrophysiological data from dog to create new models for the canine left atrium (LA), the interatrial Bachmann's bundle (BB), and the pulmonary vein (PV). The heterogeneous AP models were incorporated into a tissue strand model to simulate the AP propagation, and used to quantify conditions for conduction abnormalities (primarily, conduction block at rapid pacing rated) in the canine atria.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403810 | PMC |
| http://dx.doi.org/10.1109/IEMBS.2011.6090486 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Are drivers recurring or ephemeral? observations from serial mapping of persistent atrial fibrillation.
Europace
November 2024
Department of Biomedical Engineering, 36 S. Wasatch Drive, SMBB 3100, University of Utah, Salt Lake City, UT 84112, USA.
Aims: Rotational re-entries and ectopic foci, or 'drivers', are proposed mechanisms for persistent atrial fibrillation (persAF), but driver-based interventions have had mixed success in clinical trials. Selective targeting of drivers with multi-month stability may improve these interventions, but no prior work has investigated whether drivers can be stable on such a long timescale.
Objective: We hypothesized that drivers could recur even several months after initial observation.
Left atrial volume and function in Cavalier King Charles spaniels at different ACVIM stages.
Res Vet Sci
November 2024
Department of Veterinary Sciences, University of Torino, Largo Braccini 2, Grugliasco, TO, Italy.
Article Synopsis
- The study investigates the size and function of the left atrium in Cavalier King Charles Spaniels (CKCS) with mitral valve disease across different ACVIM stages.
- It finds that certain echocardiographic measures, like left atrial diameter normalized by body weight and various volume measurements, show significant differences between the classes of the disease's progression.
- Results indicate that active left atrial emptying is enhanced in early-stage dogs (ACVIM B1) but decreases in symptomatic cases (C/D), highlighting the presence of atrial remodeling and dysfunction as the disease advances.
Vertebral heart score and vertebral left atrial size reference intervals in Jack Russell Terriers, Miniature Pinschers, and Brussels Griffons.
Am J Vet Res
December 2024
IDEXX Laboratories, Westbrook, ME.
Objective: The investigators' hypothesis is that Jack Russell Terriers (JRTs), Miniature Pinschers (MPs), and Brussels Griffons (BGs) without underlying cardiac disease have breed-specific vertebral heart size (VHS) reference intervals.
Methods: The electronic medical records of IDEXX Telemedicine Consultants were searched for JRTs, MPs, and BGs undergoing radiography from January 1, 2023, through June 30, 2023. The study range was expanded to January 1 2022, through June 30, 2023, for BGs only to improve case volume.
In vivo cardiovascular profile of ryanodine receptor 2 inhibitor M201-A: Utility as an anti-atrial fibrillatory drug for patients suffering from heart failure with preserved ejection fraction.
J Pharmacol Sci
November 2024
Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan; Kazuya Yokoyama Cancer Research Institute, 1-4-8 Ueno, Taito-ku, Tokyo, 110-0005, Japan. Electronic address:
Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) often coexist; however, clinically available anti-AF drugs can exacerbate symptoms of HFpEF. M201-A suppressed ryanodine receptor-mediated diastolic Ca leakage, possibly inhibiting common pathological processes toward AF and HFpEF. To bridge the basic information to clinical practice, we assessed its cardiohemodynamic, anti-AF and ventricular proarrhythmic profile using halothane-anesthetized dogs (n = 4).
View Article and Find Full Text PDFRuptured left sinus of Valsalva aneurysm into the left atrium in a dog.
J Vet Cardiol
December 2024
Department of Radiology, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave. Madison, WI 53792, USA.
A dog with immune-mediated thrombocytopenia and a new heart murmur had an echocardiogram in 2016 and was found to have a suspected aorto-left atrial fistula. The echocardiogram findings remained relatively static from 2016 to 2022. This report highlights the use of cardiac-gated computed tomography angiography to allow further understanding of a complex anomaly in a patient with a ruptured sinus of Valsalva aneurysm causing a fistulous connection with the left atrium.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!