Strongyloidiasis in an immunocompromised patient has the potential to be life threatening. We describe a boy who was on steroids for acute demyelinating myelitis and receiving antibiotics for E. coli UTI and meningitis. He developed anasarca, malabsorption, malnutrition and left ventricular failure. Duodenal biopsy revealed abundant rhabditiform larvae of Strongyloides stercoralis. The diagnosis went unsuspected and proved fatal. This emphasizes the need to have a high index of suspicion and early intervention for S. stercoralis in immunosuppressed persons who present with refractory gastrointestinal symptoms.
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Front Med (Lausanne)
November 2024
Department of Gastroenterology, 108 Military Central Hospital, Hanoi, Vietnam.
Cytomegalovirus (CMV) infection is an opportunistic disease in immunocompromised patients that may appear without symptoms, with constitutional symptoms, or as a tissue-invasive disease. infection often manifests with non-specific symptoms; however, it can lead to severe malabsorption and extraintestinal dissemination by accelerated autoinfection. The coinfection of CMV and has rarely been reported, particularly with solely severe gastrointestinal bleeding.
View Article and Find Full Text PDFAm J Trop Med Hyg
December 2024
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Human strongyloidiasis is an important intestinal parasitic disease that affects public health globally and is transmitted through contact with infective larvae on contaminated soil. Immunocompromised hosts can experience hyperinfection, which can lead to fatal systemic strongyloidiasis. Here, an innovative point-of-care (POC) test kit, the strongyloidiasis immunochromatographic blood test (the NIE-SsIR whole-blood ICT) kit is described.
View Article and Find Full Text PDFToxicol Rep
December 2024
Department of Medical Sciences, School of Medical and Life Sciences, Sunway University, Malaysia.
Globally, Strongyloides stercoralis is a prevalent nematode parasite infecting over 600 million individuals, predominantly in tropical regions. Despite its widespread occurrence, it is frequently underdiagnosed and neglected, posing significant health risks, particularly to immunocompromised individuals. This parasite's life cycle includes a concerning capability for autoinfection, potentially leading to hyperinfection syndrome with high mortality rates.
View Article and Find Full Text PDFAm Surg
October 2024
Department of Surgery, Inova Fairfax Medical Campus, Falls Church, VA, USA.
Strongyloidiasis is a rare systemic parasitic infection caused by the nematode, , that is often insidious and may remain dormant for many years before progressing to fulminant hyperinfection in an immunocompromised host. In this report, we present a case of disseminated strongyloidiasis in a patient who underwent a deceased donor kidney transplantation 2 months prior to presentation. Our patient developed multisystem organ failure as well as secondary hemophagocytic lymphohistiocytosis (HLH) and ultimately died despite extensive resuscitative efforts and antiparasitic treatments.
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