Purpose: The efficacy of drinks containing low concentrations of CHO (2%-6%) on physical performance in cool and warm environments was evaluated.
Methods: In two separate but related studies, 24 healthy males completed a familiarization trial and four trials to volitional exhaustion (TTE) at 70% VO2max in cool conditions (10°C, n = 12) or 60% VO2max in a warm environment (30°C, n = 12). Subjects ingested 0%, 2%, 4%, or 6% CHO solutions (sucrose, glucose, and fructose in a ratio of 50:25:25) immediately before exercise and every 10 min during exercise.
Results: TTE in 10°C was 102.6 ± 33.9, 109.2 ± 33.9, 121.0 ± 25.7, and 122.4 ± 29.9 min in the 0%, 2%, 4%, and 6% trials, respectively (P = 0.012). Compared with the 0% trial, TTE was longer in the 4% (P = 0.032, effect size (ES) = 0.72) and 6% (P = 0.044, ES = 0.66) trials. In addition, TTE was longer in the 6% trial than in the 2% trial (P = 0.025). TTE was also significantly influenced by drink CHO content at 30°C (0% = 94.5 ± 24.5 min, 2% = 104.1 ± 20.1 min, 4% = 105.5 ± 26.7 min, 6% = 112.0 ± 28.7 min; P = 0.046). No differences in TTE were apparent between the 0% and the 2% or 4% trials, but TTE was longer in the 6% trial compared with the placebo (P = 0.045, ES = 0.62). HR, core temperature, or rates of substrate oxidation were not affected by drink CHO content.
Conclusions: These results demonstrate significant improvements in exercise capacity over the placebo trial when 4% and 6% CHO solutions were ingested at 10°C and a 6% CHO drink was ingested at 30°C.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1249/MSS.0b013e31822dc5ed | DOI Listing |
Mol Pharm
January 2025
Faculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia.
The high content of vitamin E, including tocopherols and tocotrienols (TCF-TTE), in palm oil () has made it a promising candidate for the alternative treatment of atopic dermatitis (AD). However, the limited solubility of TCF-TTE has restricted its therapeutic efficacy. In this study, pluronic-based micelles (MCs) encapsulating palm oil-derived TCF-TTE were formulated with dissolvable microarray patch-micelles (DMP-MC) using carboxymethyl cellulose (CMC) synthesized from empty fruit bunches of palm to optimize its delivery for AD.
View Article and Find Full Text PDFNutrients
December 2024
Department of Clinical Medicine, Aarhus University Hospital, Aarhus University, Palle Juul-Jensens Boulevard 165, 8200 Aarhus, Denmark.
Background: This study aimed to compare the effects of a carbohydrate (CHO) hydrogel with (ALG-CP) or without (ALG-C) branched-chain amino acids, and a CHO-only non-hydrogel (CON), on cycling performance. The hydrogels, encapsulated in an alginate matrix, are designed to control CHO release, potentially optimising absorption, increasing substrate utilisation, and reducing gastrointestinal distress as well as carious lesions.
Methods: In a randomised, double-blinded, crossover trial, 10 trained male cyclists/triathletes completed three experimental days separated by ~6 days.
Cancer Immunol Immunother
December 2024
Department of Surgical Oncology (Urology), Netherlands Cancer Institute, Amsterdam, The Netherlands.
Background: Immune checkpoint inhibitors (ICIs) are an important therapeutic pillar in metastatic urothelial carcinoma (mUC). The occurrence of immune-related adverse events (irAEs) appears to be associated with improved outcomes in observational studies. However, these associations are likely affected by immortal time bias and do not represent causal effects.
View Article and Find Full Text PDFJ Cardiovasc Dev Dis
October 2024
Department of Cardiology, Alpert Medical School of Brown University, Providence, RI 02903, USA.
Echocardiography
November 2024
Department of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Background: The transesophageal echocardiogram (TEE) is the standard imaging modality for confirming the presence or absence of patent foramen ovale. PFO is a flap valve depending on the pressure change between the left and right atrium, which can help determine whether to open. 3D-TEE was shown to optimize the visualization of PFO.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!